articleTop 1% cited
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
Nature Genetics · 2000 · Vol. 24(4) · pp. 372–376
Hitoshi Niwa✉(University of Edinburgh)Jun‐ichi Miyazaki(Osaka University)Austin Smith(University of Edinburgh)
Pluripotent Stem Cells ResearchCRISPR and Genetic EngineeringRenal and related cancersBiologyEndodermInduced pluripotent stem cellCell biologyCell fate determinationEmbryonic stem cellTranscription factorPOU domainCellular differentiationMesoderm
MeSH terms
AnimalsCell DifferentiationCell DivisionCell LineClone CellsDNA-Binding ProteinsGenes, RegulatorRNA, MessengerStem CellsTranscription FactorsTranscription, GeneticTransfectionDown-RegulationUp-RegulationGenes, Reporter
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References
Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation
Developmental Biology · 1994 · 616 citations
Efficient selection for high-expression transfectants with a novel eukaryotic vector
Gene · 1991 · 5,175 citations
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
Genes & Development · 1998 · 1,530 citations
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Proceedings of the National Academy of Sciences · 1992 · 4,950 citations
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