reviewTop 1% cited
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
Trends in Biochemical Sciences · 2009 · Vol. 34(4) · pp. 176–188
John D. Hayes✉(Ninewells Hospital)Michael McMahon(Ninewells Hospital)
Genomics, phytochemicals, and oxidative stressNitrogen and Sulfur Effects on BrassicaGlutathione Transferases and PolymorphismsKEAP1Transcription factorPsychological repressionBiologySomatic cellTranscription (linguistics)Cancer researchGeneticsOxidative stressMutation
MeSH terms
Adaptation, BiologicalAnimalsHumansModels, BiologicalMutationNeoplasmsIntracellular Signaling Peptides and ProteinsNF-E2-Related Factor 2
Funding
- Cancer Research UK
Citations
863
FWCI
26.35
field-weighted impact
References
134
Percentile
100%
vs. same field & year
Citations per year
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References
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
Molecular and Cellular Biology · 2003 · 1,425 citations
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
Molecular and Cellular Biology · 2004 · 967 citations
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Molecular and Cellular Biology · 2004 · 2,165 citations
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