reviewTop 1% cited
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
Archives of Biochemistry and Biophysics · 2010 · Vol. 501(1) · pp. 116–123
Albena T. Dinkova‐Kostova(Johns Hopkins University)Paul Talalay✉(Johns Hopkins Medicine)
Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor AgentsSirtuins and Resveratrol in MedicineNAD+ kinaseOxidative stressReactive oxygen speciesBiochemistryAntioxidantChemistryOxidoreductaseEnzymeFlavoproteinIntracellular
MeSH terms
Kelch-Like ECH-Associated Protein 1AnimalsAntioxidantsEstrogensHumansModels, BiologicalPolymorphism, GeneticProtein BindingQuinonesSignal TransductionTumor Suppressor Protein p53NAD(P)H Dehydrogenase (Quinone)Oxidative StressProteasome Endopeptidase ComplexIntracellular Signaling Peptides and Proteins
Citations
707
FWCI
15.69
field-weighted impact
References
114
Percentile
99%
vs. same field & year
Citations per year
References
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
Trends in Biochemical Sciences · 2009 · 863 citations
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Biochemical and Biophysical Research Communications · 1997 · 3,915 citations
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
Journal of Biological Chemistry · 2009 · 2,633 citations
NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger
Molecular Pharmacology · 2004 · 444 citations
SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES
Annual Review of Biochemistry · 1995 · 3,402 citations
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Genes & Development · 1999 · 3,543 citations
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
Molecular and Cellular Biology · 2004 · 967 citations
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
Molecular and Cellular Biology · 2004 · 2,165 citations
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