article Open AccessTop 1% cited
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
Breast Cancer Research and Treatment · 2005 · Vol. 91(3) · pp. 249–258
Susan Nowell✉(Roswell Park Comprehensive Cancer Center)Jiyoung Ahn(Roswell Park Comprehensive Cancer Center)James M. Rae(University of Michigan–Ann Arbor)Joshua O. Scheys(University of Michigan–Ann Arbor)A Trovato(Merck & Co., Inc., Rahway, NJ, USA (United States))Carol Sweeney(University of Utah)Stewart L. MacLeod(University of Arkansas for Medical Sciences)Fred F. Kadlubar(National Center for Toxicological Research)Christine B. Ambrosone(Roswell Park Comprehensive Cancer Center)
Pharmacogenetics and Drug MetabolismEstrogen and related hormone effectsCancer Treatment and PharmacologyTamoxifenBreast cancerOncologyInternal medicineMedicineGenotypeProportional hazards modelAlleleRetrospective cohort studyCYP2D6
MeSH terms
Breast NeoplasmsFemaleHumansMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPolymorphism, GeneticRetrospective StudiesTamoxifenGlucuronosyltransferaseGenetic VariationArylsulfotransferaseSurvival RateChemotherapy, AdjuvantAntineoplastic Agents, Hormonal
Funding
- U.S. Department of Defense
Citations
306
FWCI
17.96
field-weighted impact
References
32
Percentile
99%
vs. same field & year
Citations per year
References
Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6
Journal of Pharmacology and Experimental Therapeutics · 2004 · 643 citations
Pharmacological Characterization of 4-hydroxy-N-desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen
Breast Cancer Research and Treatment · 2004 · 455 citations
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