article Open AccessTop 1% cited
Sensitive protein alignments at tree-of-life scale using DIAMOND
Nature Methods · 2021 · Vol. 18(4) · pp. 366–368
Benjamin Buchfink✉(Max Planck Institute for Developmental Biology)Klaus Reuter(Max Planck Computing and Data Facility)Hajk‐Georg Drost(Max Planck Institute for Developmental Biology)
Abstract
We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.
Genomics and Phylogenetic StudiesMachine Learning in BioinformaticsRNA and protein synthesis mechanismsTree of life (biology)DiamondTree (set theory)Computer scienceMatching (statistics)Scale (ratio)Computational biologySensitivity (control systems)BiologyData mining
MeSH terms
AlgorithmsProteinsSequence AlignmentComputational Biology
Funding
- Max-Planck-Gesellschaft
Citations
4,573
FWCI
225.26
field-weighted impact
References
34
Percentile
100%
vs. same field & year
Citations per year
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