reviewTop 1% cited
Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy
Applied Microbiology and Biotechnology · 2019 · Vol. 104(2) · pp. 575–587
Zhenru Xu✉(First Affiliated Hospital of University of South China)Xu Han(Central South University)Daming Ou(First Affiliated Hospital of University of South China)Ting Liu(University of South China)Zunxiong Li(University of South China)Guanmin Jiang(Fifth Affiliated Hospital of Sun Yat-sen University)Jing Liu(Central South University)Ji Zhang(University of South China)
Autophagy in Disease and TherapyPolyamine Metabolism and ApplicationsPI3K/AKT/mTOR signaling in cancerAutophagyPI3K/AKT/mTOR pathwayProtein kinase BRPTORCancer researchDiscovery and development of mTOR inhibitorsChemistryBiologyCell biologyBiochemistry
MeSH terms
AnimalsAutophagyHumansNeoplasmsSignal TransductionPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesCarcinogenesis
Funding
- National Natural Science Foundation of China
Citations
620
FWCI
39.92
field-weighted impact
References
115
Percentile
100%
vs. same field & year
Citations per year
References
Targeting the phosphoinositide 3-kinase pathway in cancer
Nature Reviews Drug Discovery · 2009 · 2,742 citations
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Nature Cell Biology · 2013 · 1,512 citations
Sorafenib
Drugs · 2009 · 483 citations
Mechanism and medical implications of mammalian autophagy
Nature Reviews Molecular Cell Biology · 2018 · 2,711 citations
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