article Open AccessTop 1% cited
Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Cell Metabolism · 2019 · Vol. 30(1) · pp. 143–156.e5
Xingzhe Ma(Houston Methodist)Enguang Bi(Houston Methodist)Yong Lu(Wake Forest University)Su Pan(Houston Methodist)Chunjian Huang(Houston Methodist)Lintao Liu(Houston Methodist)Qiang Wang(Houston Methodist)Maojie Yang(Houston Methodist)Matthew F. Kalady(Cleveland Clinic)Jianfei Qian(Houston Methodist)Aijun Zhang(Houston Methodist)Anisha A. Gupte(Houston Methodist)Dale J. Hamilton(Houston Methodist)Chengyun Zheng(Second Hospital of Shandong University)Qing Yi✉(Houston Methodist)
Immune Cell Function and InteractionCancer Immunotherapy and BiomarkersCancer, Lipids, and MetabolismXBP1Cytotoxic T cellCD8Tumor microenvironmentT cellImmune systemCholesterolBiologyImmunotherapyCell biology
MeSH terms
AnimalsCholesterolFlow CytometryHumansImmunotherapyMelanoma, ExperimentalBlotting, WesternCD8-Positive T-LymphocytesImmunoprecipitationMiceTumor MicroenvironmentReal-Time Polymerase Chain ReactionProgrammed Cell Death 1 Receptor
Funding
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute
Citations
944
FWCI
27.28
field-weighted impact
References
45
Percentile
100%
vs. same field & year
Citations per year
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T cell exhaustion
Nature Immunology · 2011 · 3,925 citations
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
Cancer Research · 2011 · 1,624 citations
Immune checkpoints and their inhibition in cancer and infectious diseases
European Journal of Immunology · 2017 · 533 citations
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Cell Metabolism · 2017 · 1,139 citations
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