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Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Cell Metabolism · 2017 · Vol. 25(6) · pp. 1282–1293.e7
Alessia AngelinLuis Gil‐de‐GómezSatinder DahiyaJing JiaoLili GuoMatthew H. LevineZhong Lin WangWilliam J. QuinnPiotr KopińskiLiqing WangTatiana AkimovaYujie LiuTricia BhattiRongxiang HanBenjamin L. LaskinJoseph A. BaurIan A. BlairDouglas C. WallaceWayne W. HancockUlf H. Beier
Immune Cell Function and InteractionT-cell and B-cell ImmunologyGenomics, phytochemicals, and oxidative stressImmune systemFOXP3BiologyGlycolysisImmune toleranceTumor microenvironmentCancer cellCell biologyMetabolismCancer research

MeSH terms

AnimalsCell LineGlucoseGlycolysisHumansMice, Inbred BALB COxidative PhosphorylationProto-Oncogene Proteins c-mycMice, KnockoutLactic AcidT-Lymphocytes, RegulatoryMiceForkhead Transcription FactorsCellular MicroenvironmentCellular Reprogramming

Funding

  • Howard Hughes Medical Institute
  • Laffey-McHugh Foundation
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