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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Nature Neuroscience · 2019 · Vol. 22(3) · pp. 401–412

Evandro Fei Fang✉(National Institutes of Health)Yujun Hou(National Institutes of Health)Konstantinos Palikaras(University of Crete)Bryan A. Adriaanse(University of Oxford)Jesse S. Kerr(National Institutes of Health)Beimeng Yang(National Institutes of Health)Sofie Lautrup(National Institutes of Health)Md Mahdi Hasan‐Olive(University of Oslo)Domenica Caponio(University of Oslo)Xiuli Dan(National Institutes of Health)Paula Rocktäschel(University of Oxford)Deborah L. Croteau(National Institutes of Health)Mansour Akbari(University of Copenhagen)Nigel H. Greig(National Institutes of Health)Tormod Fladby(University of Oslo)Hilde Nilsen(University of Oslo)M. Zameel Cader(University of Oxford)Mark P. Mattson(National Institutes of Health)Nektarios Tavernarakis(University of Crete)Vilhelm A. Bohr(University of Copenhagen)

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Alzheimer's disease research and treatments Autophagy in Disease and Therapy Neuroinflammation and Neurodegeneration MechanismsTau pathologyNeuroscienceMitophagyDiseaseAmyloid βCognitionAmyloid (mycology)NeurodegenerationMedicineAlzheimer's disease

MeSH terms

Alzheimer DiseaseAnimalsDisease Models, AnimalFemaleHippocampusMaleMemoryNeuronsAmyloid beta-PeptidesCaenorhabditis elegansAnimals, Genetically ModifiedMiceInduced Pluripotent Stem CellsNeural Stem CellsMitophagy