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THE GENETICS OF CAENORHABDITIS ELEGANS

Genetics · 1974 · Vol. 77(1) · pp. 71–94

Sydney Brenner✉(Medical Research Council)

Abstract

Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.

Genetics, Aging, and Longevity in Model OrganismsBiologyCaenorhabditis elegansComplementationGeneticsMutantCaenorhabditisMutationGeneDrosophila (subgenus)Chromosome

MeSH terms

AnimalsChromosome MappingCrosses, GeneticFemaleGenes, LethalGenetic Complementation TestGenetics, BehavioralGenetic LinkageMaleMesylatesMovementMutationNematodaNervous System Physiological PhenomenaPhenotype

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