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Autophagy in major human diseases

The EMBO Journal · 2021 · Vol. 40(19) · pp. e108863–e108863

Daniel J. Klionsky✉(University of Michigan)Giulia Petroni(Cornell University)Ravi K. Amaravadi(University of Pennsylvania)Eric H. Baehrecke(University of Massachusetts Chan Medical School)Andrea Ballabio(Baylor College of Medicine)Patricia Boya(Centro de Investigaciones Biológicas Margarita Salas)José Manuel Bravo‐San Pedro(Universidad Complutense de Madrid)Ken Cadwell(NYU Langone Health)Francesco Cecconi(University of Rome Tor Vergata)Augustine M.K. Choi(NewYork–Presbyterian Hospital)Mary E. Choi(NewYork–Presbyterian Hospital)Charleen T. Chu(University of Pittsburgh)Patrice Codogno(Centre National de la Recherche Scientifique)María Isabel Colombo(Consejo Nacional de Investigaciones Científicas y Técnicas)Ana María Cuervo(Albert Einstein College of Medicine)Vojo Deretić(University of New Mexico)Ivan Đikić(Goethe University Frankfurt)Zvulun Elazar(Weizmann Institute of Science)Eeva‐Liisa Eskelinen(University of Turku)Gian María Fimia(Istituti di Ricovero e Cura a Carattere Scientifico)David A. Gewirtz(Virginia Commonwealth University)Douglas R. Green(St. Jude Children's Research Hospital)Malene Hansen(Sanford Burnham Prebys Medical Discovery Institute)Marja Jäättelä(University of Copenhagen)Terje Johansen(UiT The Arctic University of Norway)Gábor Juhász(Eötvös Loránd University)Vassiliki Karantza(Merck & Co., Inc., Rahway, NJ, USA (United States))Claudine Kraft(University of Freiburg)Guido Kroemer(Karolinska University Hospital)Nicholas T. Ktistakis(Babraham Institute)Sharad Kumar(University of South Australia)Carlos López-Otı́n(Universidad de Oviedo)Kay F. Macleod(University of Chicago)Frank Madeo(University of Graz)Jennifer Martinez(National Institute of Environmental Health Sciences)Alicia Meléndez(Queens College, CUNY)Noboru Mizushima(The University of Tokyo)Christian Münz(University of Zurich)Josef Penninger(Institute of Molecular Biotechnology)Rushika M. Perera(University of California, San Francisco)Mauro Piacentini(University of Rome Tor Vergata)Fulvio Reggiori(University Medical Center Groningen)David C. Rubinsztein(University of Cambridge)Kevin M. Ryan(Cancer Research UK Scotland Institute)Junichi Sadoshima(Rutgers, The State University of New Jersey)Laura Santambrogio(Cornell University)Luca Scorrano(University of Padua)Hans‐Uwe Simon(University of Bern)Anna Katharina Simon(University of Oxford)Anne Simonsen(Oslo University Hospital)Alexandra Stolz(Goethe University Frankfurt)Nektarios Tavernarakis(University of Crete)Sharon A. Tooze(The Francis Crick Institute)Tamotsu Yoshimori(The University of Osaka)Junying Yuan(Harvard University)Zhenyu Yue(Allen Institute for Brain Science)Qing Zhong(Shanghai Jiao Tong University)Lorenzo Galluzzi(Université Paris Cité)Federico Pietrocola(Karolinska Institutet)

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Abstract

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Autophagy in Disease and Therapy Parkinson's Disease Mechanisms and Treatments Cannabis and Cannabinoid ResearchBiologyAutophagyVirologyComputational biologyGeneticsApoptosis

MeSH terms

AnimalsAutophagyDisease SusceptibilityGene Expression RegulationHomeostasisHumansOrgan SpecificitySignal TransductionBiomarkersGenetic Predisposition to DiseaseHost-Pathogen Interactions