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RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

Hepatology · 2017 · Vol. 67(6) · pp. 2254–2270

Mengnuo Chen(University of Hong Kong)Lai Wei(University of Hong Kong)Cheuk‐Ting Law(University of Hong Kong)Felice Ho‐Ching Tsang(University of Hong Kong)Jialing Shen(University of Hong Kong)Carol Lai‐Hung Cheng(University of Hong Kong)Long‐Hin Tsang(University of Hong Kong)Daniel Wai‐Hung Ho(University of Hong Kong)David Kung‐Chun Chiu(University of Hong Kong)Joyce Man‐Fong Lee(University of Hong Kong)Carmen Chak‐Lui Wong✉(University of Hong Kong)Irene Oi‐Lin Ng✉(University of Hong Kong)Chun‐Ming Wong✉(University of Hong Kong)

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Abstract

METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270).

RNA modifications and cancer Cancer-related molecular mechanisms research RNA Research and SplicingMethyltransferaseGene silencingRNABiologyCancer researchN6-MethyladenosineGeneticsMethylationGene

MeSH terms

AnimalsCarcinoma, HepatocellularHumansLiver NeoplasmsMethyltransferasesRNA-Binding ProteinsDisease ProgressionRNA InterferenceSuppressor of Cytokine Signaling ProteinsMice

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METTL3-mediated m <sup>6</sup> A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance