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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics · 2018 · Vol. 50(5) · pp. 668–681

eQTLGen✉(The University of Queensland)Naomi R. Wray(Broad Institute)23andMe(Aarhus University)Stephan Ripke(Broad Institute)Manuel Mattheisen(The University of Queensland)Maciej Trzaskowski(The University of Queensland)Enda M. Byrne(The University of Queensland)Abdel Abdellaoui(Amsterdam Public Health)Mark J. Adams(The University of Adelaide)Esben Agerbo(Aarhus University)Tracy Air(Virginia Commonwealth University)Till F. M. Andlauer(Munich Cluster for Systems Neurology)Silviu‐Alin Bacanu(Virginia Commonwealth University)Marie Bækvad‐Hansen(Statens Serum Institut)Aartjan T.F. Beekman(GGZ inGeest)Tim B. Bigdeli(Genetics and IVF Institute)Elisabeth B. Binder(Emory University)Douglas Blackwood(Aarhus University)Julien Bryois(Statens Serum Institut)Henriette N. Buttenschøn(European Bioinformatics Institute)Jonas Bybjerg‐Grauholm(Statens Serum Institut)Na Cai(European Bioinformatics Institute)Enrique Castelao(University Hospital of Lausanne)Jane Christensen(King's College London)Toni‐Kim Clarke(QIMR Berghofer Medical Research Institute)Jonathan R. I. Coleman(The University of Queensland)Lucía Colodro‐Conde(QIMR Berghofer Medical Research Institute)Baptiste Couvy‐Duchesne(The University of Queensland)Nick Craddock(University of North Carolina at Chapel Hill)Gregory E. Crawford(Broad Institute)Cheynna Crowley(University of North Carolina at Chapel Hill)Hassan S. Dashti(Broad Institute)Gail Davies(University of Bonn)Ian J. Deary(QIMR Berghofer Medical Research Institute)Franziska Degenhardt(University of Bonn)Eske M. Derks(QIMR Berghofer Medical Research Institute)Neşe Direk(Broad Institute)Conor V. Dolan(King's College London)Erin C. Dunn(Broad Institute)Thalia C. Eley(King's College London)Nicholas Eriksson(University of British Columbia)Valentina Escott‐Price(Harvard University)Farnush Hassan Farhadi Kiadeh(University of Bonn)Hilary K. Finucane(Harvard University)Andreas J. Forstner(University of Bonn)Josef Frank(Trinity College Dublin)Héléna A. Gaspar(University of North Carolina at Chapel Hill)Michael Gill(Johns Hopkins University)Paola Giusti‐Rodríguez(University of North Carolina at Chapel Hill)Fernando S. Goes(Johns Hopkins University)Scott D. Gordon(QIMR Berghofer Medical Research Institute)Jakob Grove(Aarhus University)Lynsey S. Hall(Statens Serum Institut)Eilís Hannon(University of Exeter)Christine Søholm Hansen(Statens Serum Institut)Thomas Folkmann Hansen(The University of Sydney)Stefan Herms(University of Bonn)Ian B. Hickie(The University of Sydney)Per Hoffmann(Roche (Switzerland))Georg Homuth(Universität Greifswald)Carsten Horn(Statens Serum Institut)Jouke‐Jan Hottenga(Cleveland Clinic)David M. Hougaard(Statens Serum Institut)Ming Hu(Cleveland Clinic)Craig Hyde(Pfizer (United States))Marcus Ising(Max Planck Institute of Psychiatry)Rick Jansen(Kaiser Permanente)Fulai Jin(University of Southern California)Eric Jorgenson(Brigham and Women's Hospital)James A. Knowles(University of Southern California)Isaac S. Kohane(Brigham and Women's Hospital)Julia Kraft(University of Copenhagen)Warren W. Kretzschmar(SIB Swiss Institute of Bioinformatics)Jesper Krogh(University of Copenhagen)Zoltán Kutalik(SIB Swiss Institute of Bioinformatics)Jacqueline M. Lane(Broad Institute)Yihan Li(University of North Carolina at Chapel Hill)Yun Li(University of North Carolina at Chapel Hill)Penelope A. Lind(QIMR Berghofer Medical Research Institute)Xiaoxiao Liu(Case Western Reserve University)Leina Lu(Johns Hopkins University)Donald J. MacIntyre(The University of Queensland)Dean F. MacKinnon(University of Bonn)Robert Maier(The University of Queensland)Wolfgang Maier(University of Bonn)Jonathan Marchini(University of Oxford)Hamdi Mbarek(King's College London)Patrick J. McGrath(QIMR Berghofer Medical Research Institute)Peter McGuffin(The University of Queensland)Sarah E. Medland(QIMR Berghofer Medical Research Institute)Divya Mehta(Queensland University of Technology)Christel M. Middeldorp(The University of Queensland)Evelin Mihailov(University of Tartu)Yuri Milaneschi(University of Exeter)Lili Milani(Johns Hopkins University)Jonathan Mill(The University of Queensland)Francis M. Mondimore(University of British Columbia)Grant W. Montgomery(The University of Queensland)Sara Mostafavi(University of British Columbia)Niamh Mullins(University of British Columbia)Matthias Nauck(Universitätsmedizin Greifswald)Bernard Ng(University of British Columbia)Michel G. Nivard(King's College London)Dale R. Nyholt(Queensland University of Technology)Paul F. O’Reilly(Cardiff University)Högni Óskarsson(QIMR Berghofer Medical Research Institute)Michael J. Owen(Aarhus University)Jodie N. Painter(Aarhus University)Carsten Bøcker Pedersen(Virginia Commonwealth University)Marianne Giørtz Pedersen(Aarhus University)Roseann E. Peterson(Virginia Commonwealth University)Erik Pettersson(University Hospital of Lausanne)Wouter J. Peyrot(GGZ inGeest)Giorgio Pistis(Brigham and Women's Hospital)Daniëlle Posthuma(Solidus Biosciences (United States))Shaun Purcell(Brigham and Women's Hospital)Jorge A. Quiroz(Washington University in St. Louis)Per Qvist(Virginia Commonwealth University)John P. Rice(King's College London)Brien P. Riley(Virginia Commonwealth University)Margarita Rivera(Universidad de Granada)Saira Saeed Mirza(University Medical Center Groningen)Richa Saxena(Broad Institute)Robert A. Schoevers(University Medical Center Groningen)Eva C. Schulte(National Cancer Institute)Ling Shen(Kaiser Permanente)Jianxin Shi(University of Iceland)Stanley I. Shyn(Kaiser Permanente)Engilbert Sigurðsson(University of Iceland)Grant B. C. Sinnamon(University of Glasgow)Johannes H. Smit(deCODE Genetics (Iceland))Daniel J. Smıth(deCODE Genetics (Iceland))Hreinn Stefánsson(deCODE Genetics (Iceland))Stacy Steinberg(deCODE Genetics (Iceland))Craig A. Stockmeier(Heidelberg University)Fabian Streit(Heidelberg University)Jana Strohmaier(Heidelberg University)Katherine E. Tansey(Universitätsmedizin Greifswald)Henning Teismann(Oslo University Hospital)Alexander Teumer(Universitätsmedizin Greifswald)Wesley K. Thompson(Oslo University Hospital)Pippa A. Thomson(23andMe (United States))Thorgeir E. Thorgeirsson(deCODE Genetics (Iceland))Chao Tian(Heidelberg University)Matthew Traylor(University of Cambridge)Jens Treutlein(Heidelberg University)Vassily Trubetskoy(Roche (Switzerland))André G. Uitterlinden(Universitätsmedizin Greifswald)Daniel Umbricht(Roche (Switzerland))Sandra Van der Auwera(Universitätsmedizin Greifswald)Albert M. van Hemert(The University of Queensland)Alexander Viktorin(Oslo University Hospital)Peter M. Visscher(The University of Queensland)Yunpeng Wang(Oslo University Hospital)Bradley T. Webb(Virginia Commonwealth University)Shantel Weinsheimer(Mental Health Services)Jürgen Wellmann(Heidelberg University)Gonneke Willemsen(The University of Queensland)Stephanie H. Witt(Pfizer (United States))Yang Wu(The University of Queensland)Hualin Simon Xi(The University of Queensland)Jian Yang(The University of Queensland)Futao Zhang(The University of Queensland)Volker Arolt(University of Münster)Bernhard T. Baune(Amsterdam Public Health)Kenneth I. Berger(University of Basel)Dorret I. Boomsma(University of Münster)Sven Cichon(University of Bonn)Udo Dannlowski(Johns Hopkins University)E. C. J. de Geus(University of Trento)J. Raymond DePaulo(Johns Hopkins University)Enrico Domenici(University of Trento)Katharina Domschke(University of Freiburg)Tōnu Esko(Broad Institute)Hans J. Grabe(Universitätsmedizin Greifswald)Steven P. Hamilton(Kaiser Permanente)Caroline Hayward(23andMe (United States))Andrew C. Heath(Virginia Commonwealth University)David A. Hinds(23andMe (United States))Kenneth S. Kendler(Virginia Commonwealth University)Stefan Kloiber(Centre for Addiction and Mental Health)Glyn Lewis(Max Planck Institute of Psychiatry)Qingqin S. Li(Washington University in St. Louis)Susanne Lucae(Karolinska Institutet)Pamela Madden(Washington University in St. Louis)Patrik K. E. Magnusson(Karolinska Institutet)Nicholas G. Martin(QIMR Berghofer Medical Research Institute)Andrew M. McIntosh(Aarhus University Hospital)Andres Metspalu(Aarhus University)Ole Mors(University of Liverpool)Preben Bo Mortensen(Aarhus University)Bertram Müller‐Myhsok(University of Bonn)Merete Nordentoft(Copenhagen University Hospital)Markus M. Nöthen(University of Bonn)Michael O’Donovan(Karolinska Institutet)Sara A. Paciga(Pfizer (United States))Nancy L. Pedersen(Harvard University)Brenda W.J.H. Penninx(GGZ inGeest)Roy H. Perlis(University of Iowa)David J. Porteous(University Hospital of Lausanne)James B. Potash(University of Iowa)Martin Preisig(Kaiser Permanente)Marcella Rietschel(Heidelberg University)Catherine Schaefer(Broad Institute)Thomas G. Schulze(deCODE Genetics (Iceland))Jordan W. Smoller(Broad Institute)Hreinn Stefánsson(Dalhousie University)Henning Tiemeier(Universitätsmedizin Greifswald)Rudolf Uher(Dalhousie University)Henry Völzke(University of Copenhagen)Myrna M. Weissman(Pfizer (United States))Thomas Werge(University of Copenhagen)Ashley R. Winslow(Pfizer (United States))Cathryn M. Lewis(King's College London)Douglas F. Levinson(Aarhus University)Gerome Breen✉(University of North Carolina at Chapel Hill)Anders D. Børglum(Aarhus University)Patrick F. Sullivan(University of North Carolina at Chapel Hill)

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Genetic Associations and Epidemiology Genetics and Neurodevelopmental Disorders BRCA gene mutations in cancerBiologyGenome-wide association studyGenetic architectureGenetic associationComputational biologyAssociation (psychology)GeneticsEvolutionary biologySingle-nucleotide polymorphismQuantitative trait locus

MeSH terms

Depressive Disorder, MajorMajor Depressive DisorderFemaleHumansMalePhenotypeRisk FactorsSchizophreniaCase-Control StudiesGenetic Predisposition to DiseaseMultifactorial InheritancePolymorphism, Single NucleotideGenome-Wide Association Study