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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Nature Genetics · 2018 · Vol. 51(1) · pp. 63–75
Ditte DemontisRaymond K. WaltersJoanna MartinManuel MattheisenThomas D. AlsEsben AgerboGísli BaldurssonRich BelliveauJonas Bybjerg‐GrauholmMarie Bækvad‐HansenFelecia CerratoKimberly ChambertClaire ChurchhouseAshley DumontNicholas ErikssonMichael J. GandalJacqueline I. GoldsteinKatrina L. GrasbyJakob GroveÓlafur Ó. GuðmundssonChristine Søholm HansenMads E. HaubergMads V. HollegaardDaniel P. HowriganHailiang HuangJulian MallerAlicia R. MartinNicholas G. MartinJennifer L. MoranJonatan PallesenDuncan S. PalmerCarsten Bøcker PedersenMarianne Giørtz PedersenTimothy PoterbaJesper Buchhave PoulsenStephan RipkeElise RobinsonF. Kyle SatterstromHreinn StefánssonChristine StevensPatrick TurleyG. Bragi WaltersHyejung WonMargaret J. WrightOle A. AndreassenPhilip AshersonChristie L. BurtonDorret I. BoomsmaBru CormandSøren DalsgaardBarbara FrankeJoel GelernterDaniel H. GeschwindHåkon HåkonarsonJan HaavikHenry R. KranzlerJonna KuntsiK. LangleyKlaus‐Peter LeschChristel M. MiddeldorpAndreas ReifLuís Augusto RohdePanos RoussosRussell SchacharPamela SklarEdmund Sonuga‐BarkePatrick F. SullivanAnita ThaparJoyce Y. TungIrwin D. WaldmanSarah E. MedlandKāri StefánssonMerete NordentoftDavid M. HougaardThomas WergeOle MorsPreben Bo MortensenMark J. DalyStephen V. FaraoneAnders D. BørglumBenjamin M. Neale
Attention Deficit Hyperactivity DisorderGenetics and Neurodevelopmental DisordersGenetic Associations and EpidemiologyBiologyAttention deficit hyperactivity disorderGenome-wide association studyGenomeGeneticsComputational biologyGenePsychiatrySingle-nucleotide polymorphismGenotype

MeSH terms

AdolescentAttention Deficit Disorder with HyperactivityBrainChildChild, PreschoolFemaleGene Expression RegulationHumansMaleRiskCohort StudiesGenetic Predisposition to DiseasePolymorphism, Single NucleotideGenome-Wide Association StudyGenetic Loci

Funding

  • U.S. Department of Veterans Affairs
  • Alzheimer's Association
  • Eli Lilly and Company
  • Pfizer
  • Massachusetts General Hospital
  • Aarhus Universitet
  • Sunovion
  • Wellcome Trust
  • Indivior
  • QIMR Berghofer Medical Research Institute
  • Broad Institute
  • American Society of Clinical Psychopharmacology
  • Action Medical Research
  • King's College London
  • Deutsche Forschungsgemeinschaft
  • Generalitat de Catalunya
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • Ministerio de Economía y Competitividad
  • Lundbeckfonden
  • KU Leuven
  • Novo Nordisk
  • Universitetet i Bergen
  • Norges Forskningsråd
  • European College of Neuropsychopharmacology
  • Servier
  • H. Lundbeck A/S
  • National Institutes of Health
  • Horizon 2020 Framework Programme
  • Canadian Institutes of Health Research
  • Medical Research Council
  • National Health and Medical Research Council
  • Agència de Gestió d'Ajuts Universitaris i de Recerca
  • Seventh Framework Programme
  • National Institute of Mental Health
  • Cilag
Citations
2,287
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References
Molecular Genetics of Attention-Deficit/Hyperactivity Disorder
Biological Psychiatry · 2005 · 2,356 citations
GCTA: A Tool for Genome-wide Complex Trait Analysis
The American Journal of Human Genetics · 2010 · 9,109 citations
MAGMA: Generalized Gene-Set Analysis of GWAS Data
PLoS Computational Biology · 2015 · 3,882 citations
A linear complexity phasing method for thousands of genomes
Nature Methods · 2011 · 2,049 citations
A global reference for human genetic variation
Nature · 2015 · 19,538 citations
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