review Open AccessTop 1% cited
Targeting the DNA Damage Response in Cancer
Molecular Cell · 2015 · Vol. 60(4) · pp. 547–560
Mark J. O’Connor✉(AstraZeneca (United Kingdom))
DNA Repair MechanismsPARP inhibition in cancer therapyCell death mechanisms and regulationBiologyDNA damageCancerDNAComputational biologyCancer researchGenetics
MeSH terms
AnimalsAntineoplastic AgentsDNA DamageDNA RepairHumansNeoplasmsGenomic InstabilityMolecular Targeted Therapy
Citations
1,490
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39.77
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References
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
New England Journal of Medicine · 2015 · 9,308 citations
Causes and consequences of replication stress
Nature Cell Biology · 2013 · 2,023 citations
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
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The DNA Damage Response: Making It Safe to Play with Knives
Molecular Cell · 2010 · 4,258 citations
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Cancer Research · 2012 · 2,130 citations
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
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Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial
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