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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Nature Medicine · 2017 · Vol. 23(6) · pp. 703–713

Ahmet Zehir✉(Memorial Sloan Kettering Cancer Center)Ryma Benayed(Memorial Sloan Kettering Cancer Center)Ronak Shah(Memorial Sloan Kettering Cancer Center)Aijazuddin Syed(Memorial Sloan Kettering Cancer Center)Sumit Middha(Memorial Sloan Kettering Cancer Center)Hyunjae R. Kim(Memorial Sloan Kettering Cancer Center)Preethi Srinivasan(Memorial Sloan Kettering Cancer Center)Jianjiong Gao(Memorial Sloan Kettering Cancer Center)Debyani Chakravarty(Memorial Sloan Kettering Cancer Center)Sean M. Devlin(Memorial Sloan Kettering Cancer Center)Matthew D. Hellmann(Memorial Sloan Kettering Cancer Center)David Barron(Memorial Sloan Kettering Cancer Center)Alison M. Schram(Memorial Sloan Kettering Cancer Center)Meera Hameed(Memorial Sloan Kettering Cancer Center)Snjezana Doğan(Memorial Sloan Kettering Cancer Center)Dara S. Ross(Memorial Sloan Kettering Cancer Center)Jaclyn F. Hechtman(Memorial Sloan Kettering Cancer Center)Deborah F. DeLair(Memorial Sloan Kettering Cancer Center)JinJuan Yao(Memorial Sloan Kettering Cancer Center)Diana Mandelker(Memorial Sloan Kettering Cancer Center)Donavan T. Cheng(Memorial Sloan Kettering Cancer Center)Raghu Chandramohan(Memorial Sloan Kettering Cancer Center)Abhinita Mohanty(Memorial Sloan Kettering Cancer Center)Ryan Ptashkin(Memorial Sloan Kettering Cancer Center)Gowtham Jayakumaran(Memorial Sloan Kettering Cancer Center)Meera Prasad(Memorial Sloan Kettering Cancer Center)Mustafa Syed(Memorial Sloan Kettering Cancer Center)Anoop Balakrishnan Rema(Memorial Sloan Kettering Cancer Center)Zhen Y. Liu(Memorial Sloan Kettering Cancer Center)Khédoudja Nafa(Memorial Sloan Kettering Cancer Center)Laetitia Borsu(Memorial Sloan Kettering Cancer Center)Justyna Sadowska(Memorial Sloan Kettering Cancer Center)Jacklyn Casanova(Memorial Sloan Kettering Cancer Center)Ruben Bacares(Memorial Sloan Kettering Cancer Center)Iwona Kiecka(Memorial Sloan Kettering Cancer Center)Anna Razumova(Memorial Sloan Kettering Cancer Center)Julie B Son(Memorial Sloan Kettering Cancer Center)Lisa Stewart(Memorial Sloan Kettering Cancer Center)Tessara Baldi(Memorial Sloan Kettering Cancer Center)Kerry Mullaney(Memorial Sloan Kettering Cancer Center)Hikmat Al‐Ahmadie(Memorial Sloan Kettering Cancer Center)Efsevia Vakiani(Memorial Sloan Kettering Cancer Center)Adam Abeshouse(Memorial Sloan Kettering Cancer Center)Alexander Penson(Memorial Sloan Kettering Cancer Center)Philip Jonsson(Memorial Sloan Kettering Cancer Center)Niedzica Camacho(Memorial Sloan Kettering Cancer Center)Matthew T. Chang(Memorial Sloan Kettering Cancer Center)Helen Won(Memorial Sloan Kettering Cancer Center)Benjamin Groß(Memorial Sloan Kettering Cancer Center)Ritika Kundra(Memorial Sloan Kettering Cancer Center)Zachary Heins(Memorial Sloan Kettering Cancer Center)Hsiao‐Wei Chen(Memorial Sloan Kettering Cancer Center)Sarah Phillips(Memorial Sloan Kettering Cancer Center)Hongxin Zhang(Memorial Sloan Kettering Cancer Center)Jiaojiao Wang(Memorial Sloan Kettering Cancer Center)Angelica Ochoa(Memorial Sloan Kettering Cancer Center)Jonathan Wills(Memorial Sloan Kettering Cancer Center)Michael Eubank(Memorial Sloan Kettering Cancer Center)Stacy B. Thomas(Memorial Sloan Kettering Cancer Center)Stuart M. Gardos(Memorial Sloan Kettering Cancer Center)Dalicia N. Reales(Memorial Sloan Kettering Cancer Center)Jesse Galle(Memorial Sloan Kettering Cancer Center)Robert Durany(Memorial Sloan Kettering Cancer Center)Roy Cambria(Memorial Sloan Kettering Cancer Center)Wassim Abida(Memorial Sloan Kettering Cancer Center)Andrea Cercek(Memorial Sloan Kettering Cancer Center)Darren R. Feldman(Memorial Sloan Kettering Cancer Center)Mrinal M. Gounder(Memorial Sloan Kettering Cancer Center)A. Ari Hakimi(Memorial Sloan Kettering Cancer Center)James J. Harding(Memorial Sloan Kettering Cancer Center)Gopa Iyer(Memorial Sloan Kettering Cancer Center)Yelena Y. Janjigian(Memorial Sloan Kettering Cancer Center)Emmet Jordan(Memorial Sloan Kettering Cancer Center)Ciara M. Kelly(Memorial Sloan Kettering Cancer Center)Maeve A. Lowery(Memorial Sloan Kettering Cancer Center)Luc G.T. Morris(Memorial Sloan Kettering Cancer Center)Antonio Omuro(Memorial Sloan Kettering Cancer Center)Nitya Raj(Memorial Sloan Kettering Cancer Center)Pedram Razavi(Memorial Sloan Kettering Cancer Center)Alexander N. Shoushtari(Memorial Sloan Kettering Cancer Center)Neerav Shukla(Memorial Sloan Kettering Cancer Center)Tara E. Soumerai(Memorial Sloan Kettering Cancer Center)Anna M. Varghese(Memorial Sloan Kettering Cancer Center)Rona Yaeger(Memorial Sloan Kettering Cancer Center)Jonathan Coleman(Memorial Sloan Kettering Cancer Center)Bernard H. Bochner(Memorial Sloan Kettering Cancer Center)Gregory J. Riely(Memorial Sloan Kettering Cancer Center)Leonard B. Saltz(Memorial Sloan Kettering Cancer Center)Howard I. Scher(Memorial Sloan Kettering Cancer Center)Paul Sabbatini(Memorial Sloan Kettering Cancer Center)Mark E. Robson(Memorial Sloan Kettering Cancer Center)David S. Klimstra(Memorial Sloan Kettering Cancer Center)Barry S. Taylor(Memorial Sloan Kettering Cancer Center)José Baselga(Memorial Sloan Kettering Cancer Center)Nikolaus Schultz(Memorial Sloan Kettering Cancer Center)David M. Hyman(Memorial Sloan Kettering Cancer Center)Maria E. Arcila(Memorial Sloan Kettering Cancer Center)David B. Solit(Memorial Sloan Kettering Cancer Center)Marc Ladanyi(Memorial Sloan Kettering Cancer Center)Michael F. Berger(Memorial Sloan Kettering Cancer Center)

View via DOI Publisher page

Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations Epigenetics and DNA MethylationPrecision oncologyCancerClinical trialPrecision medicineSomatic cellMedicineComputational biologyGeneBioinformaticsOncology

MeSH terms

DNA, NeoplasmFeasibility StudiesFemaleHumansMaleMutationNeoplasm MetastasisNeoplasmsProspective StudiesBiomarkers, TumorCohort StudiesSequence Analysis, DNAGenomicsData MiningHigh-Throughput Nucleotide Sequencing

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3,455

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100%

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