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Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Nature Genetics · 2019 · Vol. 51(2) · pp. 202–206

Robert Samstein✉(Memorial Sloan Kettering Cancer Center)Chung‐Han Lee(Memorial Sloan Kettering Cancer Center)Alexander N. Shoushtari(Memorial Sloan Kettering Cancer Center)Matthew D. Hellmann(Memorial Sloan Kettering Cancer Center)Ronglai Shen(Memorial Sloan Kettering Cancer Center)Yelena Y. Janjigian(Memorial Sloan Kettering Cancer Center)David Barron(Memorial Sloan Kettering Cancer Center)Ahmet Zehir(Memorial Sloan Kettering Cancer Center)Emmet Jordan(Memorial Sloan Kettering Cancer Center)Antonio Omuro(Memorial Sloan Kettering Cancer Center)Thomas Kaley(Memorial Sloan Kettering Cancer Center)Sviatoslav M. Kendall(Memorial Sloan Kettering Cancer Center)Robert J. Motzer(Memorial Sloan Kettering Cancer Center)A. Ari Hakimi(Memorial Sloan Kettering Cancer Center)Martin H. Voss(Memorial Sloan Kettering Cancer Center)Paul Russo(Memorial Sloan Kettering Cancer Center)Jonathan E. Rosenberg(Memorial Sloan Kettering Cancer Center)Gopa Iyer(Memorial Sloan Kettering Cancer Center)Bernard H. Bochner(Memorial Sloan Kettering Cancer Center)Dean F. Bajorin(Memorial Sloan Kettering Cancer Center)Hikmat Al‐Ahmadie(Memorial Sloan Kettering Cancer Center)Jamie E. Chaft(Memorial Sloan Kettering Cancer Center)Charles M. Rudin(Memorial Sloan Kettering Cancer Center)Gregory J. Riely(Memorial Sloan Kettering Cancer Center)Shrujal S. Baxi(Memorial Sloan Kettering Cancer Center)Alan L. Ho(Memorial Sloan Kettering Cancer Center)Richard J. Wong(Memorial Sloan Kettering Cancer Center)David G. Pfister(Memorial Sloan Kettering Cancer Center)Jedd D. Wolchok(Memorial Sloan Kettering Cancer Center)Christopher A. Barker(Memorial Sloan Kettering Cancer Center)Philip H. Gutin(Memorial Sloan Kettering Cancer Center)Cameron Brennan(Memorial Sloan Kettering Cancer Center)Viviane Tabar(Memorial Sloan Kettering Cancer Center)Ingo K. Mellinghoff(Memorial Sloan Kettering Cancer Center)Lisa M. DeAngelis(Memorial Sloan Kettering Cancer Center)Charlotte E. Ariyan(Memorial Sloan Kettering Cancer Center)Nancy Y. Lee(Memorial Sloan Kettering Cancer Center)William D. Tap(Memorial Sloan Kettering Cancer Center)Mrinal M. Gounder(Memorial Sloan Kettering Cancer Center)Sandra P. D’Angelo(Cornell University)Leonard B. Saltz(Memorial Sloan Kettering Cancer Center)Zsofia K. Stadler(Memorial Sloan Kettering Cancer Center)Howard I. Scher(Memorial Sloan Kettering Cancer Center)José Baselga(Memorial Sloan Kettering Cancer Center)Pedram Razavi(Memorial Sloan Kettering Cancer Center)Christopher A. Klebanoff(Memorial Sloan Kettering Cancer Center)Rona Yaeger(Memorial Sloan Kettering Cancer Center)Neil H. Segal(Memorial Sloan Kettering Cancer Center)Geoffrey Y. Ku(Memorial Sloan Kettering Cancer Center)Ronald P. DeMatteo(Memorial Sloan Kettering Cancer Center)Marc Ladanyi(Memorial Sloan Kettering Cancer Center)Naiyer A. Rizvi(Columbia University Irving Medical Center)Michael F. Berger(Memorial Sloan Kettering Cancer Center)Nadeem Riaz(Memorial Sloan Kettering Cancer Center)David B. Solit(Memorial Sloan Kettering Cancer Center)Timothy A. Chan(Memorial Sloan Kettering Cancer Center)Luc G.T. Morris(Memorial Sloan Kettering Cancer Center)

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Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Lung Cancer Treatments and MutationsBiologyCancerOncologyImmunotherapyInternal medicineOverall survivalSurvival analysisSomatic cellCancer researchMedicine