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Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

Cell Metabolism · 2016 · Vol. 24(4) · pp. 593–607
Åsa SegerstolpeAthanasia PalasantzaPernilla EliassonEva-Marie AnderssonAnne‐Christine AndréassonXiaoyan SunSimone PicelliAlan SabirshMaryam ClausenMagnus BjursellDavid M. SmithMaria KasperCarina ÄmmäläRickard Sandberg
Pancreatic function and diabetesDiabetes and associated disordersPhagocytosis and Immune RegulationTranscriptomeBiologyIsletParacrine signallingCell typeType 2 diabetesEnteroendocrine cellGene expression profilingGlucose homeostasisPancreatic islets

MeSH terms

Glucagon-Like Peptide-1 ReceptorDiabetes Mellitus, Type 2HumansIslets of LangerhansMaleObesityTissue DonorsTranscription FactorsReproducibility of ResultsGene Expression ProfilingSingle-Cell Analysis

Funding

  • Science for Life Laboratory
Citations
1,694
FWCI
115.80
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54
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References
Adipokines in health and disease
Trends in Pharmacological Sciences · 2015 · 1,005 citations
Full-length RNA-seq from single cells using Smart-seq2
Nature Protocols · 2014 · 4,437 citations
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