review Open AccessTop 1% cited
Mechanism and Regulation of NLRP3 Inflammasome Activation
Trends in Biochemical Sciences · 2016 · Vol. 41(12) · pp. 1012–1021
Yuan He(University of Michigan–Ann Arbor)Hideki Hara(University of Michigan–Ann Arbor)Gabriel Núñez✉(University of Michigan–Ann Arbor)
Inflammasome and immune disordersIL-33, ST2, and ILC PathwaysGout, Hyperuricemia, Uric AcidInflammasomeMechanism (biology)ChemistryCell biologyBiologyBiochemistryReceptorPhysics
MeSH terms
PyroptosisNLR Family, Pyrin Domain-Containing 3 ProteinNIMA-Related KinasesAnimalsGene Expression RegulationHumansLipopolysaccharidesMacrophagesMonocytesPotassiumSignal TransductionIon TransportCaspase 1Interleukin-18Mice
Funding
- National Institutes of Health
Citations
2,654
FWCI
80.59
field-weighted impact
References
82
Percentile
100%
vs. same field & year
Citations per year
Cited by
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Circulation Research · 2018 · 1,950 citations
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation
Cell Death and Disease · 2020 · 375 citations
NLRP3 inflammasome in endothelial dysfunction
Cell Death and Disease · 2020 · 463 citations
NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling
Cell Death and Disease · 2019 · 378 citations
References
The Inflammasome
Molecular Cell · 2002 · 5,936 citations
Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K <sup>+</sup> efflux
European Journal of Immunology · 2015 · 502 citations
Function of Nod‐like receptors in microbial recognition and host defense
Immunological Reviews · 2008 · 881 citations
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Cell Death and Differentiation · 2007 · 1,418 citations
Regulation of inflammasome activation
Immunological Reviews · 2015 · 1,061 citations
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Immunity · 2012 · 2,103 citations
Initiation and perpetuation of <scp>NLRP</scp>3 inflammasome activation and assembly
Immunological Reviews · 2015 · 832 citations
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Immunity · 2013 · 2,085 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.