article Open AccessTop 1% cited
Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
Genome biology · 2016 · Vol. 17(1) · pp. 174–174
Bo Li✉(Harvard University)Eric A. Severson(Dana-Farber Cancer Institute)Jean‐Christophe Pignon(Brigham and Women's Hospital)Haoquan Zhao(Dana-Farber Cancer Institute)Taiwen Li(Sichuan University)Jesse Novak(Harvard University)Peng Jiang(Dana-Farber Cancer Institute)Hui Shen(Van Andel Institute)Jon C. Aster(Brigham and Women's Hospital)Scott J. Rodig(Brigham and Women's Hospital)Sabina Signoretti(Brigham and Women's Hospital)Jun S. Liu(Harvard University)X. Shirley Liu(Dana-Farber Cancer Institute)
Abstract
We develop a computational approach to study tumor-infiltrating immune cells and their interactions with cancer cells. Our resource of immune-infiltrate levels, clinical associations, as well as predicted therapeutic markers may inform effective cancer vaccine and checkpoint blockade therapies.
Cancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune cells in cancerBiologyImmune systemImmunotherapyCancer immunotherapyImmune checkpointCancerMelanomaImmunologyCancer immunologyTumor-infiltrating lymphocytes
MeSH terms
Disease SusceptibilityHumansImmune SystemImmunityImmunotherapyModels, BiologicalNeoplasmsBiomarkers, TumorGenetic VariationSignal TransductionGene Expression Regulation, NeoplasticLymphocytes, Tumor-InfiltratingDatabases, GeneticMolecular Targeted Therapy
Funding
- National Natural Science Foundation of China
- National Cancer Institute
Citations
2,741
FWCI
38.45
field-weighted impact
References
46
Percentile
100%
vs. same field & year
Citations per year
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