review Open AccessTop 1% cited
The blockade of immune checkpoints in cancer immunotherapy
Nature reviews. Cancer · 2012 · Vol. 12(4) · pp. 252–264
Drew M. Pardoll✉(Sidney Kimmel Comprehensive Cancer Center)
Cancer Immunotherapy and BiomarkersImmune Cell Function and InteractionCAR-T cell therapy researchImmune systemImmunotherapyImmune checkpointImmunologyAntigenBlockadeBiologyCancer immunotherapyImmunityCytotoxic T cell
MeSH terms
AnimalsAntigens, NeoplasmClinical Trials as TopicHumansImmunotherapyNeoplasmsTumor EscapeCancer VaccinesMolecular Targeted TherapyCTLA-4 AntigenProgrammed Cell Death 1 Receptor
Funding
- Melanoma Research Alliance
- Hussman Foundation
Citations
13,550
FWCI
190.50
field-weighted impact
References
129
Percentile
100%
vs. same field & year
Citations per year
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References
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
The EMBO Journal · 1992 · 3,162 citations
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
Nature Medicine · 1999 · 2,463 citations
Up on the tightrope: natural killer cell activation and inhibition
Nature Immunology · 2008 · 1,637 citations
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>
Science · 2003 · 8,062 citations
Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
Journal of Clinical Oncology · 2010 · 2,913 citations
Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
Blood · 2009 · 1,751 citations
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Nature Medicine · 2002 · 4,970 citations
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
Immunity · 2007 · 1,731 citations
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