article Open AccessTop 1% cited

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Nature Medicine · 2018 · Vol. 24(10) · pp. 1550–1558

Peng Jiang✉(Harvard University)Shengqing Gu(Dana-Farber Cancer Institute)Deng Pan(Harvard University)Jingxin Fu(Tongji University)Avinash Sahu(Harvard University)Xihao Hu(Harvard University)Ziyi Li(Tongji University)Nicole Traugh(Dana-Farber Cancer Institute)Xia Bu(Dana-Farber Cancer Institute)Bo Li(Harvard University)Jun Liu(Harvard University)Gordon J. Freeman(Dana-Farber Cancer Institute)Myles Brown(Dana-Farber Cancer Institute)Kai W. Wucherpfennig(Harvard University)X. Shirley Liu(Tongji University)

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Cancer Immunotherapy and Biomarkers Cancer Genomics and Diagnostics Ferroptosis and cancer prognosisImmune checkpointImmunotherapyCTL*Immune systemBlockadeCytotoxic T cellCancer researchMelanomaMedicineInfiltration (HVAC)

MeSH terms

AnimalsAntibodies, MonoclonalDisease Models, AnimalHumansImmunotherapyMelanoma, ExperimentalNeoplasm ProteinsT-Lymphocytes, CytotoxicSerpinsLymphocytes, Tumor-InfiltratingCD8-Positive T-LymphocytesMiceTumor MicroenvironmentB7-H1 AntigenCTLA-4 Antigen

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