articleTop 1% cited
The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module
Molecular Pharmacology · 1999 · Vol. 56(6) · pp. 1329–1339
Bryan Goodwin✉(Westmead Hospital)Ecushla Hodgson(Westmead Hospital)Christopher Liddle(The University of Sydney)
Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsEstrogen and related hormone effectsPregnane X receptorEnhancerMolecular biologyBiologyCYP3A4Reporter geneTranscription (linguistics)Transcription factorPromoterMutant
MeSH terms
Retinoic Acid Receptor alphaPregnane X ReceptorAnimalsAntibiotics, AntitubercularBase SequenceCytochrome P-450 Enzyme SystemDeoxyribonuclease IDNAEnhancer Elements, GeneticEnzyme InductionHumansMixed Function OxygenasesMolecular Sequence DataReceptors, SteroidRifampin
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References
MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS
Annual Review of Biochemistry · 1994 · 2,881 citations
The nuclear receptor superfamily: The second decade
Cell · 1995 · 6,961 citations
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