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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
JAMA · 2016 · Vol. 315(8) · pp. 801–801
Mervyn Singer(University College London)Clifford S. Deutschman✉(Feinstein Institute for Medical Research)Christopher W. Seymour(University of Pittsburgh)Manu Shankar‐Hari(Guy's and St Thomas' NHS Foundation Trust)Djillali Annane(Institut Lavoisier de Versailles)Michael Bauer(Jena University Hospital)Rinaldo Bellomo(Australian and New Zealand Intensive Care Society)Gordon R. Bernard(Vanderbilt University)Jean‐Daniel Chiche(Hôpital Cochin)Craig M. Coopersmith(Emory University)Richard S. Hotchkiss(Washington University in St. Louis)Mitchell M. Levy(Brown University)John C. Marshall(University of Toronto)Greg S. Martin(Emory University)Steven M. Opal(Brown University)Gordon D. Rubenfeld(Health Sciences Centre)Tom van der Poll(Academic Medical Center)Jean‐Louis Vincent(Erasmus Hospital)Derek C. Angus(UPMC Health System)
Abstract
These updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsis or at risk of developing sepsis.
Sepsis Diagnosis and TreatmentHemodynamic Monitoring and TherapyIntensive Care Unit Cognitive DisordersSepsisMedicineSeptic shockIntensive care medicineOrgan dysfunctionSystemic inflammatory response syndromeSOFA scoreEpidemiologyShock (circulatory)Immunology
MeSH terms
Blood PressureDelphi TechniqueHumansLactatesTerminology as TopicSensitivity and SpecificityShock, SepticVasoconstrictor AgentsBiomarkersHospital MortalityPeer Review, ResearchSystemic Inflammatory Response SyndromeSepsisAdvisory CommitteesInternational Classification of Diseases
Funding
- American Thoracic Society
- AstraZeneca
- University of Pennsylvania
- Pennsylvania State University
- CSL Behring
- European Respiratory Society
- American Association of Critical-Care Nurses
- Wellcome Trust
- European Resuscitation Council
- European Commission
- Intensive Care Society
- Academy of Medical Royal Colleges
- European Society of Clinical Microbiology and Infectious Diseases
- Universitätsklinikum Jena
- European Society of Intensive Care Medicine
- InflaRx
- National Institutes of Health
- Centers for Disease Control and Prevention
- Defence Science and Technology Laboratory
Citations
27,000
FWCI
1348.24
field-weighted impact
References
51
Percentile
100%
vs. same field & year
Citations per year
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References
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Critical Care Medicine · 1998 · 3,473 citations
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Intensive Care Medicine · 2014 · 1,738 citations
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
Critical Care Medicine · 1999 · 1,332 citations
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Nature reviews. Immunology · 2013 · 2,562 citations
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
Critical Care Medicine · 2003 · 5,994 citations
Benchmarking the Incidence and Mortality of Severe Sepsis in the United States*
Critical Care Medicine · 2013 · 1,343 citations
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
Intensive Care Medicine · 2007 · 4,939 citations
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