articleTop 1% cited
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
Critical Care Medicine · 1999 · Vol. 27(7) · pp. 1230–1251
Richard S. Hotchkiss✉(Washington University in St. Louis)Paul E. Swanson(Washington University in St. Louis)Bradley D. Freeman(Washington University in St. Louis)Kevin W. Tinsley(Washington University in St. Louis)J. Perren Cobb(Washington University in St. Louis)George M. Matuschak(Washington University in St. Louis)Timothy G. Buchman(Washington University in St. Louis)Irene E. Karl(Washington University in St. Louis)
Abstract
We conclude that caspase-3-mediated apoptosis causes extensive lymphocyte apoptosis in sepsis and may contribute to the impaired immune response that characterizes the disorder.
Cell death mechanisms and regulationSepsis Diagnosis and TreatmentVibrio bacteria research studiesMedicineH&E stainTUNEL assayApoptosisSepsisSeptic shockPathologyOrgan dysfunctionImmunohistochemistryGastroenterology
MeSH terms
AdultAgedAged, 80 and overAutopsyEnzyme PrecursorsFemaleHumansImmunohistochemistryIntestinesLymphocytesMaleMiddle AgedMultiple Organ FailureProspective StudiesShock, Septic
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References
Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family
Journal of Cerebral Blood Flow & Metabolism · 1998 · 546 citations
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Critical Care Medicine · 1996 · 989 citations
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
British Journal of Cancer · 1972 · 15,557 citations
A cautionary note on the use of the TUNEL stain to determine apoptosis
Neuroreport · 1995 · 509 citations
Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis
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