article Open Access
Erythropoietin prevents liver injury in septic mice
International Journal of Chemical Studies · 2020 · Vol. 8(4) · pp. 3720–3725
K Kannan✉(Indian Veterinary Research Institute)Sujata Maiti Choudhury(Indian Veterinary Research Institute)Thamil Selvee Ramasamy(Indian Veterinary Research Institute)Manickam Kesavan(Indian Veterinary Research Institute)Subhashree Parida(Indian Veterinary Research Institute)Thakur Uttam Singh(Tamil Nadu Veterinary and Animal Sciences University)
Abstract
In the present study, the effect of erythropoietin in liver of septic mice was investigated. Sepsis was induced by caecal ligation and puncture model. After 20+2 hrs of surgery, blood and liver samples were collected. Plasma TNF-α, IL-1β, Serum AST, ALT and Liver lipid peroxidation, myeloperoxidase, thiols was estimated and histopathology was performed. Post-treatment with erythropoietin ameliorated the sepsis induced changes in hepatic and systemic inflammatory changes in mice.
Erythropoietin and Anemia TreatmentErythrocyte Function and PathophysiologyPhytochemicals and Medicinal PlantsErythropoietinSepsisMedicineHistopathologyLiver injuryMyeloperoxidaseLipid peroxidationInternal medicineGastroenterologyImmunology
Citations
0
FWCI
0.00
field-weighted impact
References
26
Percentile
11%
vs. same field & year
References
Prognosis in Acute Organ-System Failure
Annals of Surgery · 1985 · 1,238 citations
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent
Analytical Biochemistry · 1968 · 7,959 citations
Oxidative stress and gene expression in sepsis
British Journal of Anaesthesia · 2003 · 490 citations
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
JAMA · 2016 · 27,000 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.