article Open AccessTop 10% cited
Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14
American Journal Of Pathology · 2012 · Vol. 182(2) · pp. 375–387
Shuhong Guo(Raymond G. Murphy VA Medical Center)Rana Al–Sadi(Radiology Associates of Albuquerque)Hamid M. Said(University of California, Irvine)Y. Thomas✉(Raymond G. Murphy VA Medical Center)
Barrier Structure and Function StudiesGut microbiota and healthInflammatory Bowel DiseaseEnterocyteLipopolysaccharideTight junctionIntestinal permeabilityIn vivoCD14Paracellular transportIntracellularCaco-2Inflammation
MeSH terms
AnimalsCell MembraneCell Membrane PermeabilityHumansLipopolysaccharidesMaleMice, Inbred C57BLTime FactorsUp-RegulationApoptosisCaco-2 CellsLipopolysaccharide ReceptorsTight JunctionsGene SilencingEnterocytes
Funding
- U.S. Department of Veterans Affairs
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Research Resources
Citations
677
FWCI
10.41
field-weighted impact
References
60
Percentile
98%
vs. same field & year
Citations per year
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References
Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects1
Journal of Animal Science · 2008 · 523 citations
Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2009 · 484 citations
Intestinal mucosal barrier function in health and disease
Nature reviews. Immunology · 2009 · 3,701 citations
TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules
Molecular Pharmacology · 2010 · 580 citations
TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2004 · 871 citations
Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2011 · 403 citations
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