reviewTop 1% cited
Intestinal mucosal barrier function in health and disease
Nature reviews. Immunology · 2009 · Vol. 9(11) · pp. 799–809
Jerrold R. Turner✉(University of Chicago)
Gut microbiota and healthBarrier Structure and Function StudiesHelicobacter pylori-related gastroenterology studiesImmune systemBarrier functionSecretionCell biologyDiseaseBiologyImmunologyEpitheliumFunction (biology)Medicine
MeSH terms
AnimalsCell Membrane PermeabilityCytoskeletonEpithelial CellsHomeostasisHumansIntestinal DiseasesIntestinal MucosaMembrane ProteinsCytokinesImmunity, MucosalTight JunctionsGastrointestinal Tract
Citations
3,701
FWCI
40.07
field-weighted impact
References
122
Percentile
100%
vs. same field & year
Citations per year
Cited by
Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2011 · 403 citations
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
Immunological Reviews · 2014 · 1,294 citations
Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2017 · 360 citations
Leaky gut: mechanisms, measurement and clinical implications in humans
Gut · 2019 · 993 citations
Leaky Gut As a Danger Signal for Autoimmune Diseases
Frontiers in Immunology · 2017 · 591 citations
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
Lab on a Chip · 2012 · 1,664 citations
Regulation of intestinal epithelial permeability by tight junctions
Cellular and Molecular Life Sciences · 2012 · 1,274 citations
Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment
Nephrology Dialysis Transplantation · 2015 · 374 citations
References
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
Gastroenterology · 2006 · 1,612 citations
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Journal of Biological Chemistry · 1996 · 2,003 citations
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
Journal of Cell Science · 2002 · 797 citations
Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression
American Journal Of Pathology · 2005 · 675 citations
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
The Journal of Experimental Medicine · 2007 · 2,639 citations
Increased expression of interleukin 17 in inflammatory bowel disease
Gut · 2002 · 1,688 citations
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation
American Journal of Physiology-Cell Physiology · 1997 · 540 citations
Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression
American Journal of Physiology-Gastrointestinal and Liver Physiology · 2005 · 442 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.