article Open AccessTop 1% cited

Chemotherapy‐driven dysbiosis in the intestinal microbiome

Alimentary Pharmacology & Therapeutics · 2015 · Vol. 42(5) · pp. 515–528

Emmanuel Montassier✉(University of Minnesota)Thomas Gastinne(Nantes Université)Pajau Vangay(University of Minnesota)Gabriel A. Al‐Ghalith(University of Minnesota)Stanislas Bruley des Varannes(Centre Hospitalier Universitaire de Nantes)Sébastien Massart(University of Liège)Philippe Moreau(Nantes Université)G. Potel(Nantes Université)Marie France De La Cochetiere(Inserm)Éric Batard(Nantes Université)Dan Knights✉(University of Minnesota)

View via DOI Full-text PDF

Abstract

Our study identifies a severe compositional and functional imbalance in the gut microbial community associated with chemotherapy-induced GI mucositis. The functional pathways implicated in our analysis suggest potential directions for the development of intestinal microbiome-targeted interventions in cancer patients.

Oral health in cancer treatment Head and Neck Cancer Studies Neutropenia and Cancer InfectionsMucositisMicrobiomeDysbiosisChemotherapyMedicineInternal medicineGastroenterologyHematopoietic stem cell transplantationCancer researchBiology

MeSH terms

FirmicutesBacillotaGastrointestinal MicrobiomeAdultAntineoplastic AgentsFecesFemaleHumansLymphoma, Non-HodgkinMaleMiddle AgedRNA, Ribosomal, 16SHematopoietic Stem Cell TransplantationProteobacteriaActinobacteria

Citations

487

FWCI

16.02

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

References

Energy contributions of volatile fatty acids from the gastrointestinal tract in various species