articleTop 10% cited
TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules
Molecular Pharmacology · 2010 · Vol. 79(1) · pp. 34–41
Immune Response and InflammationNF-κB Signaling PathwaysNeutrophil, Myeloperoxidase and Oxidative MechanismsSignal transducing adaptor proteinTLR4Toll-like receptorCell biologySignal transductionHEK 293 cellsReceptorChemistryBiologyMolecular biology
MeSH terms
AnimalsFemaleHumansMice, Inbred BALB CProtein BindingSulfonamidesSignal TransductionAdaptor Proteins, Signal TransducingToll-Like Receptor 4MiceHEK293 Cells
Funding
- Dainippon Sumitomo Pharma
Citations
580
FWCI
3.72
field-weighted impact
References
36
Percentile
94%
vs. same field & year
Citations per year
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Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14
American Journal Of Pathology · 2012 · 677 citations
References
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Nature reviews. Immunology · 2007 · 2,612 citations
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