article Open AccessTop 1% cited
Variance component model to account for sample structure in genome-wide association studies
Nature Genetics · 2010 · Vol. 42(4) · pp. 348–354
Hyun Min Kang(University of Michigan–Ann Arbor)Jae Hoon Sul(University of California, Los Angeles)Susan K. Service(University of California, Los Angeles)Noah Zaitlen(Harvard University)Sit-yee Kong(University of California, Los Angeles)Nelson B. Freimer(University of California, Los Angeles)Chiara Sabatti✉(Stanford University)Eleazar Eskin✉(University of California, Los Angeles)
Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsGenetic Syndromes and ImprintingGenome-wide association studyPairwise comparisonGenetic associationPrincipal component analysisVariance (accounting)Spurious relationshipBiologyMultivariate statisticsStatisticsSample size determination
MeSH terms
HumansModels, GeneticSoftwareModels, StatisticalPolymorphism, Single NucleotidePrincipal Component AnalysisQuantitative Trait LociPopulation GroupsGenome-Wide Association Study
Funding
- National Institutes of Health
- National Heart, Lung, and Blood Institute
Citations
3,011
FWCI
51.31
field-weighted impact
References
60
Percentile
100%
vs. same field & year
Citations per year
Cited by
DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation
eLife · 2015 · 557 citations
Robust relationship inference in genome-wide association studies
Bioinformatics · 2010 · 3,789 citations
Polygenic Modeling with Bayesian Sparse Linear Mixed Models
PLoS Genetics · 2013 · 928 citations
variancePartition: interpreting drivers of variation in complex gene expression studies
BMC Bioinformatics · 2016 · 848 citations
Defining the role of common variation in the genomic and biological architecture of adult human height
Nature Genetics · 2014 · 2,087 citations
Genome-wide efficient mixed-model analysis for association studies
Nature Genetics · 2012 · 3,909 citations
Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies
PLoS Genetics · 2016 · 1,590 citations
Rare-Variant Association Analysis: Study Designs and Statistical Tests
The American Journal of Human Genetics · 2014 · 1,100 citations
References
Estimation of Pairwise Relatedness With Molecular Markers
Genetics · 1999 · 1,199 citations
Introduction to quantitative genetics (4th edn)
Trends in Genetics · 1996 · 1,458 citations
Finding the missing heritability of complex diseases
Nature · 2009 · 8,468 citations
An Arabidopsis Example of Association Mapping in Structured Samples
PLoS Genetics · 2007 · 727 citations
Genomic Control for Association Studies
Biometrics · 1999 · 3,224 citations
Population Structure and Eigenanalysis
PLoS Genetics · 2006 · 5,602 citations
Efficient Control of Population Structure in Model Organism Association Mapping
Genetics · 2008 · 1,948 citations
A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
Nature Genetics · 2005 · 4,219 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.