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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Nature Genetics · 2009 · Vol. 41(10) · pp. 1088–1093

Denise Harold✉(Cardiff University)Richard Abraham(Medical Research Council)Paul Hollingworth(Medical Research Council)Rebecca Sims(Cardiff University)Amy Gerrish(Cardiff University)Marian L. Hamshere(Cardiff University)Jaspreet Singh Pahwa(Cardiff University)Valentina Moskvina(Medical Research Council)Kimberley Dowzell(Cardiff University)Amy L. Williams(Medical Research Council)Nicola Jones(Cardiff University)Charlene Thomas(Cardiff University)Alexandra Stretton(Medical Research Council)Angharad R. Morgan(Medical Research Council)Simon Lovestone(Centre for Mental Health)John Powell(King's College London)Petroula Proitsi(King's College London)Michelle K. Lupton(King's College London)Carol Brayne(Institute of Public Health)David C. Rubinsztein(University of Cambridge)Michael Gill(Trinity College Dublin)Brian Lawlor(Trinity College Dublin)Aoibhinn Lynch(Trinity College Dublin)Kevin Morgan(University of Nottingham)Kristelle Brown(Queen's Medical Centre)Peter Passmore(Queen's University Belfast)David Craig(Queen's University Belfast)Bernadette McGuinness(Queen's University Belfast)Stephen Todd(Queen's University Belfast)Clive Holmes(University of Southampton)David Mann(University of Manchester)A. David Smith(University of Oxford)Seth Love(Frenchay Hospital)Patrick G. Kehoe(Frenchay Hospital)John HardySimon Mead(University College London)Nick C. Fox(University College London)Martin N. Rossor(UK Dementia Research Institute)John Collinge(University College London)Wolfgang Maier(University of Bonn)Frank Jessen(University of Bonn)Britta Schürmann(University of Bonn)Reinhard Heun(University of Bonn)Hendrik van den Bussche(Universität Hamburg)Isabella Heuser(Charité - Universitätsmedizin Berlin)Johannes Kornhuber(Friedrich-Alexander-Universität Erlangen-Nürnberg)Jens WiltfangMartin Dichgans(LMU Klinikum)Lutz Frölich(Heidelberg University)Harald Hampel(Trinity College Dublin)Michael Hüll(University of Freiburg)Dan Rujescu(Ludwig-Maximilians-Universität München)Alison Goate(Washington University in St. Louis)John S.K. Kauwe(Brigham Young University)Carlos Cruchaga(Washington University in St. Louis)Petra Nowotny(Washington University in St. Louis)John C. Morris(Washington University in St. Louis)Kevin H. Mayo(Washington University in St. Louis)Kristel Sleegers(University of Antwerp)Karolien Bettens(VIB-UAntwerp Center for Molecular Neurology)Sebastiaan Engelborghs(ZNA Middelheim Hospital)Peter Paul De Deyn(ZNA Middelheim Hospital)Christine Van Broeckhoven(University of Antwerp)Gill Livingston(University College London)Nicholas Bass(University College London)Hugh Gurling(University College London)Andrew McQuillin(University College London)Rhian Gwilliam(Wellcome Sanger Institute)Panos Deloukas(Wellcome Sanger Institute)Ammar Al‐Chalabi(King's College London)Christopher E. Shaw(King's College London)Magda Tsolaki(Aristotle University of Thessaloniki)Andrew B. Singleton(National Institute on Aging)Rita Guerreiro(National Institute on Aging)Thomas W. Mühleisen(University of Bonn)Markus M. Nöthen(Life & Brain (Germany))Susanne Moebus(University of Duisburg-Essen)Karl‐Heinz Jöckel(University of Duisburg-Essen)Norman Klopp(Helmholtz Zentrum München)H‐Erich Wichmann(LMU Klinikum)Minerva M. Carrasquillo(Mayo Clinic in Florida)V. Shane Pankratz(Mayo Clinic)Steven G. Younkin(Jacksonville College)Peter Holmans(Cardiff University)Michael O’Donovan(Medical Research Council)Michael J. Owen(Cardiff University)Julie Williams(Cardiff University)

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Genetic Associations and Epidemiology Alzheimer's disease research and treatments Bioinformatics and Genomic NetworksGenome-wide association studySingle-nucleotide polymorphismBiologyGenetic associationOdds ratioSNPGeneticsApolipoprotein ELocus (genetics)Disease

MeSH terms

Alzheimer DiseaseChromosomes, HumanHumansGenome, HumanGenetic Predisposition to DiseasePolymorphism, Single NucleotideMonomeric Clathrin Assembly ProteinsClusterinGenome-Wide Association Study