review Open AccessTop 1% cited
Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
Biological Psychiatry · 2014 · Vol. 77(1) · pp. 43–51
Celeste M. Karch(Hope Center for Neurological Disorders)Alison Goate✉(Hope Center for Neurological Disorders)
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and SignalingTREM2DiseaseGenome-wide association studyPathogenesisBiologyGeneticsGeneGenetic associationBioinformaticsMedicine
MeSH terms
Alzheimer DiseaseCholesterolEndocytosisHumansPhenotypeRisk FactorsAmyloid beta-Protein PrecursorGenetic Predisposition to DiseasePresenilin-1Presenilin-2Genome-Wide Association Study
Citations
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References
Alzheimer’s Disease: The Challenge of the Second Century
Science Translational Medicine · 2011 · 1,414 citations
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Science · 1993 · 9,373 citations
The Role of Apolipoprotein E in Alzheimer's Disease
Neuron · 2009 · 1,622 citations
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
Science · 2002 · 13,715 citations
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
Science Translational Medicine · 2011 · 1,172 citations
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Nature Genetics · 2013 · 4,605 citations
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Nature Genetics · 2009 · 3,381 citations
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Nature Genetics · 2009 · 2,256 citations
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