reviewTop 1% cited
Targeting mitochondria for cancer therapy
Nature Reviews Drug Discovery · 2010 · Vol. 9(6) · pp. 447–464
Simone Fulda✉(University Hospital Ulm)Lorenzo Galluzzi(Délégation Ile-de-France Villejuif)Guido Kroemer(Inserm)
Mitochondrial Function and PathologyCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMitochondrionCancer cellCell biologyProgrammed cell deathOxidative phosphorylationCytosolApoptosisBioenergeticsBiologySignal transduction
MeSH terms
ResveratrolMitochondrial Permeability Transition PoreAnimalsAntineoplastic AgentsCell Membrane PermeabilityHumansIndolesMitochondriaPyrrolesStilbenesReactive Oxygen SpeciesHSP90 Heat-Shock ProteinsMitochondrial Membrane Transport Proteins
Citations
1,617
FWCI
37.33
field-weighted impact
References
249
Percentile
100%
vs. same field & year
Citations per year
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References
Mitochondrial Membrane Permeabilization in Cell Death
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AKT/PKB Signaling: Navigating Downstream
Cell · 2007 · 6,033 citations
Tumor Cell Metabolism: Cancer's Achilles' Heel
Cancer Cell · 2008 · 2,271 citations
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
Oncogene · 2006 · 2,279 citations
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
Cell Death and Differentiation · 2006 · 605 citations
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Cancer Cell · 2006 · 1,217 citations
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Cell Metabolism · 2006 · 2,210 citations
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
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