articleTop 1% cited
Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
American Journal of Respiratory and Critical Care Medicine · 2009 · Vol. 181(4) · pp. 315–323
Wendy C. Moore✉(Asthma UK)Deborah A. Meyers(Asthma UK)Sally E. Wenzel(Asthma UK)W. Gerald Teague(Asthma UK)Huashi Li(Wake Forest University)Xingnan Li(Wake Forest University)Ralph B. D’Agostino(Wake Forest University)Mario Castro(Asthma UK)Douglas Curran‐Everett(Asthma UK)Anne M. Fitzpatrick(Asthma UK)Benjamin Gaston(Asthma UK)Nizar N. Jarjour(Asthma UK)Ronald L. Sorkness(Asthma UK)William J. Calhoun(Asthma UK)Kian Fan Chung(Asthma UK)Suzy Comhair(Asthma UK)Raed A. Dweik(Asthma UK)Elliot Israel(Asthma UK)Stephen P. Peters(Asthma UK)William W. Busse(Asthma UK)Serpil C. Erzurum(Asthma UK)Eugene R. Bleecker(Asthma UK)
Abstract
Five distinct clinical phenotypes of asthma have been identified using unsupervised hierarchical cluster analysis. All clusters contain subjects who meet the American Thoracic Society definition of severe asthma, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.
Asthma and respiratory diseasesRespiratory and Cough-Related ResearchChronic Obstructive Pulmonary Disease (COPD) ResearchMedicineAsthmaBronchodilatorUnivariate analysisCluster (spacecraft)CohortComorbidityInternal medicinePediatricsMultivariate analysis
MeSH terms
AdolescentAdrenal Cortex HormonesAdultAge FactorsAgedAged, 80 and overAsthmaBronchodilator AgentsChildFemaleHumansMaleMiddle AgedPhenotypeRespiratory Function Tests
Funding
- Brigham and Women's Hospital
- Emory University
- Cleveland Clinic
- University of Pittsburgh
- Imperial College London
- National Heart, Lung, and Blood Institute
Citations
2,105
FWCI
40.66
field-weighted impact
References
51
Percentile
100%
vs. same field & year
Citations per year
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Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
American Journal of Respiratory and Critical Care Medicine · 2009 · 2,105 citations
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