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Oxone as an Inexpensive, Safe, and Environmentally Benign Oxidant for C−H Bond Oxygenation

Organic Letters · 2006 · Vol. 8(6) · pp. 1141–1144
Lopa V. DesaiHasnain A. MalikMelanie S. Sanford

Abstract

[reaction: see text] This paper describes the application of peroxide-based oxidants in the Pd(OAc)(2)-catalyzed acetoxylation and etherification of arene and alkane C-H bonds. Oxone in acetic acid and/or methanol proved particularly effective, and these transformations were applied to a wide variety of substrates.

Oxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemistryMethanolAcetic acidAlkaneCatalysisPeroxideCombinatorial chemistryOrganic chemistryOxygenationHydrogen peroxide

MeSH terms

Indicators and ReagentsPeroxidesSulfuric AcidsMolecular StructureOxidantsCombinatorial Chemistry Techniques
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