articleTop 10% cited

Novel Acetoxylation and C−C Coupling Reactions at Unactivated Positions in α-Amino Acid Derivatives

Organic Letters · 2006 · Vol. 8(15) · pp. 3391–3394

B. V. Subba Reddy✉(Harvard University)Leleti Rajender Reddy(Harvard University)E. J. Corey(Harvard University)

Abstract

[Structure: see text] Under special conditions, N-phthaloyl-alpha-amino acid amides of 8-aminoquinoline can be either acetoxylated or arylated selectively at the beta-carbon. In certain cases, arylation can be effected at the gamma-carbon.

Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions Catalytic Cross-Coupling ReactionsChemistryCoupling (piping)Amino acidCombinatorial chemistryCoupling reactionStereochemistryMedicinal chemistryOrganic chemistryBiochemistryCatalysis

MeSH terms

Amino AcidsAminoquinolinesStereoisomerismMolecular Structure

Citations

546

FWCI

9.37

field-weighted impact

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99%

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References

Oxone as an Inexpensive, Safe, and Environmentally Benign Oxidant for C−H Bond Oxygenation

Organic Letters · 2006 · 421 citations

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