article Open AccessTop 1% cited
AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients
Cancer Cell · 2007 · Vol. 11(1) · pp. 83–95
Tracy T. Batchelor✉(Harvard University)A. Gregory Sorensen(Harvard University)Emmanuelle di Tomaso(Harvard University)Wei-Ting Zhang(Harvard University)Dan G. Duda(Harvard University)Kenneth S. Cohen(Harvard University)Kevin R. Kozak(Harvard University)Daniel P. Cahill(Harvard University)Poe-Jou Chen(Harvard University)Mingwang Zhu(Harvard University)Marek Ancukiewicz(Harvard University)Maciej Mrugala(Harvard University)Scott R. Plotkin(Harvard University)Jan Drappatz(Harvard University)David N. Louis(Harvard University)Percy Ivy(National Cancer Institute)David T. Scadden(Harvard University)Thomas Benner(Harvard University)Jay S. Loeffler(Harvard University)Patrick Y. Wen(Harvard University)Rakesh K. Jain✉(Harvard University)
Angiogenesis and VEGF in CancerGlioma Diagnosis and TreatmentCancer, Hypoxia, and MetabolismTyrosine-kinase inhibitorMedicineEdemaCancer researchTyrosine kinaseReceptorInternal medicineReceptor tyrosine kinaseGlioblastomaEndocrinology
MeSH terms
Brain EdemaBrain NeoplasmsEnzyme-Linked Immunosorbent AssayFibroblast Growth FactorsFlow CytometryGlioblastomaHumansImage Processing, Computer-AssistedIndolesMagnetic Resonance ImagingNeoplastic Cells, CirculatingNeoplasm Recurrence, LocalNeovascularization, PathologicQuinazolinesNeoplastic Stem Cells
Funding
- Pfizer
- National Institutes of Health
Citations
1,760
FWCI
73.59
field-weighted impact
References
63
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100%
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Citations per year
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References
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
Cancer Research · 2004 · 1,179 citations
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
Cancer Cell · 2005 · 1,605 citations
High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results
Magnetic Resonance in Medicine · 1996 · 809 citations
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