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Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

Cancer Cell · 2012 · Vol. 22(4) · pp. 425–437

Dominik Sturm(German Cancer Research Center)Hendrik Witt(German Cancer Research Center)Volker Hovestadt(German Cancer Research Center)Dong-Anh Khuong-Quang(McGill University Health Centre)David Jones(German Cancer Research Center)Carolin Konermann(German Cancer Research Center)Elke Pfaff(German Cancer Research Center)Martje Tönjes(German Cancer Research Center)Martin Sill(German Cancer Research Center)Sebastian Bender(German Cancer Research Center)Marcel Kool(German Cancer Research Center)Marc Zapatka(German Cancer Research Center)Natália Becker(German Cancer Research Center)Manuela Zucknick(German Cancer Research Center)Thomas Hielscher(German Cancer Research Center)Xiao-Yang Liu(McGill University Health Centre)Adam M. Fontebasso(Montreal Children's Hospital)Marina Ryzhova(Burdenko Neurosurgery Institute)Steffen Albrecht(Montreal Children's Hospital)Karine Jacob(McGill University Health Centre)Marietta Wolter(Heinrich Heine University Düsseldorf)Martin Ebinger(University Children's Hospital Tübingen)Martin U. Schuhmann(University Children's Hospital Tübingen)Timothy Van Meter(Virginia Commonwealth University)Michael C. Frühwald(University Hospital Augsburg)Holger Hauch(SLK-Kliniken Heilbronn)Arnulf Pekrun(Prof. Hess Kinderklinik)Bernhard Radlwimmer(German Cancer Research Center)Tim Niehues(Helios Klinikum Krefeld)Gregor von Komorowski(Heidelberg University)Matthias Dürken(Heidelberg University)Andreas E. Kulozik(Heidelberg University)Jenny Madden(University of Colorado Denver)Andrew M. Donson(University of Colorado Denver)Nicholas K. Foreman(University of Colorado Denver)Rachid Drissi(Cincinnati Children's Hospital Medical Center)Maryam Fouladi(Cincinnati Children's Hospital Medical Center)Wolfram Scheurlen(Cnopf´sche Kinderklinik)Andreas von Deimling(German Cancer Research Center)Camelia Monoranu(University of Würzburg)Wolfgang Roggendorf(University of Würzburg)Christel Herold‐Mende(Heidelberg University)Andreas Unterberg(Heidelberg University)Christof M. Kramm(Martin Luther University Halle-Wittenberg)Jörg Felsberg(Heinrich Heine University Düsseldorf)Christian Hartmann(Medizinische Hochschule Hannover)Benedikt Wiestler(Heidelberg University)Wolfgang Wick(Heidelberg University)Till Milde(German Cancer Research Center)Olaf Witt(German Cancer Research Center)Anders M. Lindroth(German Cancer Research Center)Jeremy Schwartzentruber(McGill University and Génome Québec Innovation Centre)Damien Faury(McGill University Health Centre)Adam Fleming(McGill University Health Centre)Magdalena Zakrzewska(Medical University of Lodz)Paweł P. Liberski(Medical University of Lodz)Krzysztof Zakrzewski(Polish Mother’s Memorial Hospital Research Institute)Péter Hauser✉(Semmelweis University)Miklós Garami✉(Semmelweis University)Álmos Klekner(University of Debrecen)László Bognár(University of Debrecen)A. Sorana Morrissy(University of Toronto)Florence M.G. Cavalli(University of Toronto)Michael D. Taylor(University of Toronto)Peter van Sluis(University of Amsterdam)Jan Köster(University of Amsterdam)Rogier Versteeg(University of Amsterdam)Richard Volckmann(University of Amsterdam)Tom Mikkelsen(Henry Ford Hospital)Kenneth Aldape(The University of Texas MD Anderson Cancer Center)Guido Reifenberger(Heinrich Heine University Düsseldorf)V. Peter Collins(University of Cambridge)Jacek Majewski(McGill University)Andrey Korshunov(German Cancer Research Center)Peter Lichter(German Cancer Research Center)Christoph Plass(German Cancer Research Center)Nada Jabado(McGill University Health Centre)Stefan M. Pfister(German Cancer Research Center)

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Glioma Diagnosis and Treatment Cancer, Hypoxia, and Metabolism Cancer Genomics and DiagnosticsGlioblastomaEpigeneticsIDH1BiologyEpigenesisGeneticsCancer researchIsocitrate dehydrogenaseGeneDNA methylation

MeSH terms

AdultBrain NeoplasmsChildGlioblastomaHistonesHumansIsocitrate DehydrogenaseMutationDNA MethylationReceptor, Platelet-Derived Growth Factor alphaEpigenesis, GeneticTranscriptome