article Open AccessTop 1% cited

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Cancer Cell · 2011 · Vol. 19(1) · pp. 17–30

Wei Xu✉(Shanghai Medical College of Fudan University)Hui Yang(Shanghai Medical College of Fudan University)Ying Liu(Shanghai Medical College of Fudan University)Ying Yang(Fudan University)Ping Wang(Shanghai Medical College of Fudan University)Se Hee Kim(University of North Carolina at Chapel Hill)Shinsuke Ito(University of North Carolina at Chapel Hill)Yang Chen(Chinese Academy of Sciences)Pu Wang(Shanghai Medical College of Fudan University)Meng-Tao Xiao(Shanghai Medical College of Fudan University)Li-xia Liu(Shanghai Medical College of Fudan University)Wen-qing Jiang(Shanghai Medical College of Fudan University)Jing Liu(Chinese Academy of Sciences)Jin-ye Zhang(Shanghai Medical College of Fudan University)Bin Wang(Shanghai Medical College of Fudan University)Stephen V. Frye(University of North Carolina at Chapel Hill)Yi Zhang(University of North Carolina at Chapel Hill)Yan-hui Xu(Fudan University)Qun‐Ying Lei(Shanghai Medical College of Fudan University)Kun‐Liang Guan(Shanghai Medical College of Fudan University)Shimin Zhao(Shanghai Medical College of Fudan University)Yue Xiong(University of North Carolina at Chapel Hill)

View via DOI Full-text PDF

Glioma Diagnosis and Treatment Histone Deacetylase Inhibitors Research Epigenetics and DNA MethylationIDH2HistoneEpigeneticsIDH1BiologyHistone methylationCancer researchDemethylaseDNA methylationDNA demethylation

MeSH terms

AnimalsBinding, CompetitiveCytosineDNA-Binding ProteinsGliomaGlutaratesHistonesHumansMixed Function OxygenasesIsocitrate DehydrogenaseKetoglutaric AcidsModels, MolecularOxalatesOxidoreductases, N-DemethylatingProcollagen-Proline Dioxygenase

Citations

2,803

FWCI

84.56

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Fundamentals of cancer metabolism