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Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Cancer Cell · 2010 · Vol. 17(1) · pp. 98–110

Roel G.W. Verhaak(Harvard University)Katherine A. Hoadley(University of North Carolina at Chapel Hill)Elizabeth Purdom(University of California, Berkeley)Victoria Wang(University of California, Berkeley)Yuan Qi(University of North Carolina at Chapel Hill)Matthew D. Wilkerson(University of North Carolina at Chapel Hill)C. Ryan Miller(University of North Carolina at Chapel Hill)Li Ding(Washington University in St. Louis)Todd R. Golub(Broad Institute)Jill P. Mesirov(Harvard University)Gabriele Alexe(Harvard University)Michael S. Lawrence(Harvard University)Michael O'Kelly(Broad Institute)Pablo Tamayo(Massachusetts Institute of Technology)Barbara A. Weir(Dana-Farber Cancer Institute)Stacey Gabriel(Massachusetts Institute of Technology)Wendy Winckler(Dana-Farber Cancer Institute)Supriya Gupta(Harvard University)Lakshmi R. Jakkula(Lawrence Berkeley National Laboratory)Heidi S. Feiler(Lawrence Berkeley National Laboratory)John Hodgson(University of California, San Francisco)C. David James(Neurological Surgery)Jann N. Sarkaria(Mayo Clinic)Cameron Brennan(Memorial Sloan Kettering Cancer Center)A Kahn(SRA International (United States))Paul T. Spellman(Lawrence Berkeley National Laboratory)Richard K. Wilson(Washington University in St. Louis)Terence P. Speed(Walter and Eliza Hall Institute of Medical Research)Joe W. Gray(Lawrence Berkeley National Laboratory)Matthew Meyerson(Massachusetts Institute of Technology)Gad Getz(Harvard University)Charles M. Perou(University of North Carolina at Chapel Hill)D. Neil Hayes✉(University of North Carolina at Chapel Hill)

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Glioma Diagnosis and Treatment RNA Research and Splicing Cancer Genomics and DiagnosticsPDGFRABiologyIDH1TranscriptomeGeneCancer researchGenomeGene expression profilingSomatic cellCarcinogenesis

MeSH terms

AdultAgedBrain NeoplasmsDNA Mutational AnalysisFactor Analysis, StatisticalGlioblastomaHumansIsocitrate DehydrogenaseMiddle AgedMutationNeurofibromatosis 1PrognosisGene ExpressionGene DosageOligonucleotide Array Sequence Analysis