article Open AccessTop 1% cited
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Cancer Cell · 2006 · Vol. 10(5) · pp. 389–399
Mark F. van Delft✉(Walter and Eliza Hall Institute of Medical Research)Andrew H. Wei(Walter and Eliza Hall Institute of Medical Research)Kylie D. Mason(Walter and Eliza Hall Institute of Medical Research)Cassandra J. Vandenberg(Walter and Eliza Hall Institute of Medical Research)Lin Chen(Walter and Eliza Hall Institute of Medical Research)Peter E. Czabotar(Walter and Eliza Hall Institute of Medical Research)Simon N. Willis(Walter and Eliza Hall Institute of Medical Research)Clare L. Scott(Walter and Eliza Hall Institute of Medical Research)Catherine L. Day(University of Otago)Suzanne Cory(Walter and Eliza Hall Institute of Medical Research)Jerry M. Adams(Walter and Eliza Hall Institute of Medical Research)Andrew W. Roberts(Walter and Eliza Hall Institute of Medical Research)David C.S. Huang(Walter and Eliza Hall Institute of Medical Research)
Cell death mechanisms and regulationCancer-related Molecular PathwaysRNA Interference and Gene DeliveryDownregulation and upregulationApoptosisCancer researchBiologyCell biologyChemistryGeneBiochemistry
MeSH terms
AnimalsBiphenyl CompoundsCells, CulturedDisease Models, AnimalFibroblastsHumansMaleMice, Inbred C57BLMice, TransgenicNeoplasm ProteinsNitrophenolsPiperazinesRecombinant Fusion ProteinsSulfonamidesLeukemia, Myeloid, Acute
Funding
- Abbott Laboratories
Citations
1,217
FWCI
27.15
field-weighted impact
References
68
Percentile
100%
vs. same field & year
Citations per year
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References
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
Cancer Cell · 2002 · 1,634 citations
The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues
Molecular Cell · 2000 · 1,468 citations
The Hallmarks of Cancer
Cell · 2000 · 28,385 citations
The Bcl-2 family: roles in cell survival and oncogenesis
Oncogene · 2003 · 1,448 citations
Bim: a novel member of the Bcl-2 family that promotes apoptosis
The EMBO Journal · 1998 · 1,151 citations
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
Molecular Cell · 2005 · 1,794 citations
BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis
Molecular Cell · 2001 · 1,688 citations
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