article Open AccessTop 1% cited
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
New England Journal of Medicine · 2008 · Vol. 359(13) · pp. 1317–1329
Werner Hacke✉(Heidelberg University)Markku Kaste(Helsinki University Hospital)Erich Bluhmki(Boehringer Ingelheim (Germany))M BrozmanAntoni Dávalos(Hospital Universitari Germans Trias i Pujol)Donata Guidetti(Ospedaliera di Piacenza)Vincent Larrue(Université de Toulouse)Kennedy R. Lees(University of Glasgow)Zakaria Medeghri(Boehringer Ingelheim (France))Thomas Machnig(Boehringer Ingelheim (Germany))Dietmar Schneider(Leipzig University)Rüdiger von Kummer(TU Dresden)Nils Wahlgren(Karolinska Institutet)Danilo Toni
Abstract
As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; alteplase was more frequently associated with symptomatic intracranial hemorrhage. (ClinicalTrials.gov number, NCT00153036.)
Acute Ischemic Stroke ManagementStroke Rehabilitation and RecoveryCerebrovascular and Carotid Artery DiseasesMedicineThrombolysisStroke (engine)Ischemic strokeAcute strokeFibrinolytic agentTissue plasminogen activatorEmergency medicineAnesthesiaInternal medicine
MeSH terms
Acute DiseaseAdultAgedBrain IschemiaDouble-Blind MethodDrug Administration ScheduleFemaleFibrinolytic AgentsHumansInfusions, IntravenousMaleMiddle AgedTissue Plasminogen ActivatorTime FactorsLogistic Models
Funding
- Bristol-Myers Squibb
- Pfizer
- Sanofi
- Les Laboratories Pierre Fabre
- Novo Nordisk
- H. Lundbeck A/S
Citations
6,559
FWCI
203.99
field-weighted impact
References
23
Percentile
100%
vs. same field & year
Citations per year
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Stroke · 2007 · 2,474 citations
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Medical Entomology and Zoology · 1965 · 12,854 citations
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