article Open AccessTop 1% cited
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Gut · 2009 · Vol. 58(8) · pp. 1091–1103
Patrice D. Cani✉(UCLouvain)Sam Possemiers(Ghent University)Tom Van de Wiele(Ghent University)Yves Guiot(UCLouvain)Amandine Everard(UCLouvain)Olivier Rottier(UCLouvain)Lucie Geurts(UCLouvain)Damien Naslain(UCLouvain)Audrey M. Neyrinck(UCLouvain)D.M. Lambert(UCLouvain)Giulio G. Muccioli(UCLouvain)Nathalie M. Delzenne(UCLouvain)
Abstract
We found that a selective gut microbiota change controls and increases endogenous GLP-2 production, and consequently improves gut barrier functions by a GLP-2-dependent mechanism, contributing to the improvement of gut barrier functions during obesity and diabetes.
Gut microbiota and healthDiet and metabolism studiesDietary Effects on HealthPrebioticGut floraIntestinal permeabilityInternal medicineEndocrinologyLipopolysaccharideInflammationGlucagon-like peptide-2BiologyImmunology
MeSH terms
AnimalsBacteriaCecumHepatitisInflammationIntestinal AbsorptionMembrane ProteinsMice, ObeseObesityPermeabilityPhosphoproteinsRNA, MessengerOxidative StressTight JunctionsEndotoxemia
Funding
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
Citations
2,458
FWCI
34.02
field-weighted impact
References
90
Percentile
100%
vs. same field & year
Citations per year
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References
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Nature Medicine · 2005 · 2,216 citations
Obesity alters gut microbial ecology
Proceedings of the National Academy of Sciences · 2005 · 6,096 citations
Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
Diabetologia · 2007 · 1,744 citations
The gut microbiota as an environmental factor that regulates fat storage
Proceedings of the National Academy of Sciences · 2004 · 6,132 citations
The metabolic syndrome—a new worldwide definition
The Lancet · 2005 · 9,222 citations
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
Diabetes · 2008 · 4,637 citations
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Diabetes · 2007 · 6,292 citations
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