article Open AccessTop 1% cited
Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice
Diabetes · 2011 · Vol. 60(11) · pp. 2775–2786
Amandine Everard(UCLouvain)Vladimir Lazarević(University Hospital of Geneva)Muriel Derrien(TiFN)Myriam Girard(University Hospital of Geneva)Giulio G. Muccioli(UCLouvain)Audrey M. Neyrinck(UCLouvain)Sam Possemiers(Ghent University)Ann Van Holle(Ghent University)Patrice François(University Hospital of Geneva)Willem M. de Vos(University of Helsinki)Nathalie M. Delzenne(UCLouvain)Jacques Schrenzel(University Hospital of Geneva)Patrice D. Cani✉(UCLouvain)
Abstract
We conclude that specific gut microbiota modulation improves glucose homeostasis, leptin sensitivity, and target enteroendocrine cell activity in obese and diabetic mice. By profiling the gut microbiota, we identified a catalog of putative bacterial targets that may affect host metabolism in obesity and diabetes.
Gut microbiota and healthDiet and metabolism studiesDietary Effects on HealthPrebioticGut floraBiologyGlucose homeostasisLeptinFirmicutesEndocrinologyInternal medicineCarbohydrate metabolismDiabetes mellitus
MeSH terms
AnimalsCecumColonDiabetes Mellitus, Type 2Dietary FatsGene Expression RegulationGram-Negative BacteriaGram-Positive BacteriaHyperglycemiaHyperlipidemiasMice, Inbred C57BLMice, ObeseObesityRNA, MessengerGlucose Intolerance
Funding
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Société Francophone du Diabète
- Fonds Spéciaux de Recherche
Citations
1,053
FWCI
18.23
field-weighted impact
References
54
Percentile
100%
vs. same field & year
Citations per year
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