article Open AccessTop 10% cited
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
The EMBO Journal · 2003 · Vol. 22(23) · pp. 6267–6276
D. G. Winkler✉(Target (United States))
Bone Metabolism and DiseasesBone health and treatmentsTGF-β signaling in diseasesSclerostinOsteocyteBone morphogenetic proteinOsteoblastEndocrinologyInternal medicineBone morphogenetic protein 7BiologyCell biologyBone morphogenetic protein 2
MeSH terms
Alkaline PhosphataseAnimalsBase SequenceBone DevelopmentBone Diseases, MetabolicCell LineCloning, MolecularGenetic MarkersGlycoproteinsHumansKineticsMesodermMice, Inbred C3HMice, TransgenicOsteocytes
Citations
1,106
FWCI
7.06
field-weighted impact
References
82
Percentile
98%
vs. same field & year
Citations per year
Cited by
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
The FASEB Journal · 2005 · 957 citations
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis
Endocrine Reviews · 2010 · 1,168 citations
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
Journal of Bone and Mineral Research · 2010 · 780 citations
Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
Journal of Bone and Mineral Research · 2009 · 619 citations
Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis
Journal of Bone and Mineral Research · 2008 · 778 citations
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Bone · 2011 · 458 citations
SOST is a target gene for PTH in bone
Bone · 2005 · 612 citations
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
Journal of Bone and Mineral Research · 2008 · 937 citations
References
A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait
The American Journal of Human Genetics · 2002 · 1,291 citations
Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein
The American Journal of Human Genetics · 2001 · 1,008 citations
Ion motive ATPases. I. Ubiquity, properties, and significance to cell function
Trends in Biochemical Sciences · 1987 · 963 citations
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Human Molecular Genetics · 2001 · 1,146 citations
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Science · 1999 · 20,977 citations
Related articles
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
The EMBO Journal · 2003 · 1,106 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
