article Open AccessTop 1% cited
Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
Bone · 2011 · Vol. 50(1) · pp. 209–217
Xiaolin Tu(Indiana University – Purdue University Indianapolis)Yumie Rhee(Indiana University School of Medicine)Keith W. Condon(Indiana University – Purdue University Indianapolis)Nicoletta Bivi(Indiana University School of Medicine)Matthew R. Allen(Indiana University – Purdue University Indianapolis)Denise Dwyer(Amgen (United States))Marina Stolina(Amgen (United States))Charles H. Turner(Indiana University – Purdue University Indianapolis)Alexander G. Robling(Indiana University School of Medicine)Lilian I. Plotkin(Indiana University School of Medicine)Teresita Bellido✉(Indiana University School of Medicine)
Genetics and Physical PerformanceMuscle Physiology and DisordersBone health and osteoporosis researchSclerostinWnt signaling pathwayOsteocyteDownregulation and upregulationChemistryGenetically modified mouseEndocrinologyTransgeneBone remodelingInternal medicine
MeSH terms
AnimalsFemaleGenetic MarkersGlycoproteinsHumansMaleMice, TransgenicOsteocytesOsteogenesisStress, MechanicalSignal TransductionDown-RegulationWeight-BearingTransgenesBone Morphogenetic Proteins
Funding
- National Institutes of Health
Citations
458
FWCI
17.20
field-weighted impact
References
43
Percentile
99%
vs. same field & year
Citations per year
References
Effects of biomechanical stress on bones in animals
Bone · 2002 · 454 citations
Osteocytes, mechanosensing and Wnt signaling
Bone · 2008 · 1,055 citations
SOST is a target gene for PTH in bone
Bone · 2005 · 612 citations
Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein
The American Journal of Human Genetics · 2001 · 1,008 citations
Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
Journal of Bone and Mineral Research · 2009 · 619 citations
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
Journal of Bone and Mineral Research · 2008 · 937 citations
Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee
Journal of Bone and Mineral Research · 1987 · 5,021 citations
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Human Molecular Genetics · 2001 · 1,146 citations
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