articleTop 1% cited
The Effect of Temperature and pH on the Activity of Factor VIIa: Implications for the Efficacy of High-Dose Factor VIIa in Hypothermic and Acidotic Patients
The Journal of Trauma: Injury, Infection, and Critical Care · 2003 · Vol. 55(5) · pp. 886–891
Zhi Hong Meng✉(Duke University Hospital)Alisa S. WolbergDougald M. MonroeMaureane Hoffman(Durham VA Medical Center)
Abstract
FVIIa should be effective in enhancing hemostasis in hypothermic patients. However, because the activity of FVIIa is so dramatically affected by pH, its efficacy may be reduced in acidotic patients.
Trauma, Hemostasis, Coagulopathy, ResuscitationHemophilia Treatment and ResearchMuscle and Compartmental DisordersRecombinant factor VIIaMedicineHemostasisPlateletTissue factorHypothermiaCoagulationFactor VIIaAcidosisPharmacology
MeSH terms
AcidosisAdultBlood PlateletsHemostasisHumansHydrogen-Ion ConcentrationHypothermiaMiddle AgedPhospholipidsTemperatureThromboplastinFactor VIIa
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References
Recombinant Activated Factor VII for Adjunctive Hemorrhage Control in Trauma
The Journal of Trauma: Injury, Infection, and Critical Care · 2001 · 448 citations
Platelet activity of high‐dose factor VIIa is independent of tissue factor
British Journal of Haematology · 1997 · 538 citations
Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
Biochimica et Biophysica Acta (BBA) - Biomembranes · 1985 · 2,057 citations
Hypothermia in Trauma Victims
The Journal of Trauma: Injury, Infection, and Critical Care · 1987 · 680 citations
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