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Acute Coagulopathy of Trauma: Hypoperfusion Induces Systemic Anticoagulation and Hyperfibrinolysis
The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · Vol. 64(5) · pp. 1211–1217
Karim Brohi✉(Royal London Hospital)Mitchell J. CohenMichael T. GanterMarcus J. SchultzMarcel LeviRobert C. MackersieJean‐François Pittet
Abstract
Acute coagulopathy of trauma is associated with systemic hypoperfusion and is characterized by anticoagulation and hyperfibrinolysis. There was no evidence of coagulation factor loss or dysfunction at this time point. Soluble thrombomodulin levels correlate with thrombomodulin activity. Thrombin binding to thrombomodulin contributes to hyperfibrinolysis via activated protein C consumption of PAI-1.
Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesSepsis Diagnosis and TreatmentHyperfibrinolysisThrombomodulinCoagulopathyFibrinolysisMedicineFibrinogenProtein CThromboelastographyPartial thromboplastin timeInternal medicine
MeSH terms
Blood Coagulation FactorsDisseminated Intravascular CoagulationFibrinolysisHumansProspective StudiesProtein CTrauma CentersWounds and InjuriesInjury Severity Score
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726
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References
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The Journal of Trauma: Injury, Infection, and Critical Care · 2003 · 1,708 citations
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The Journal of Trauma: Injury, Infection, and Critical Care · 1992 · 402 citations
Fresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion
The Journal of Trauma: Injury, Infection, and Critical Care · 2007 · 567 citations
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The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · 726 citations
Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials
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