review Open AccessTop 1% cited
St John's wort (<i>Hypericum perforatum</i>): drug interactions and clinical outcomes
British Journal of Clinical Pharmacology · 2002 · Vol. 54(4) · pp. 349–356
Lindsay M. Henderson✉(European Medicines Agency)Qun‐Ying Yue(Medical Products Agency)Carin Bergquist(Medical Products Agency)Barbro Gerdén(Medical Products Agency)Peter Arlett
Abstract
In Sweden and the UK the potential risks to patients were judged to be significant and therefore information about the interactions was provided to health care professionals and patients. The product information of the licensed medicines involved has been amended to reflect these newly identified interactions and SJW preparations have been voluntarily labelled with appropriate warnings.
Complementary and Alternative Medicine StudiesNatural Compound Pharmacology StudiesHerbal Medicine Research StudiesHypericum perforatumMedicinePharmacologyTriptansDrug interactionCYP3A4DrugMigraineIntensive care medicinePsychiatry
MeSH terms
Contraceptives, OralDigoxinDrug InteractionsHumansPlant ExtractsTheophyllineWarfarinCyclosporineHIV Protease InhibitorsSelective Serotonin Reuptake InhibitorsHypericumHerb-Drug Interactions
Citations
368
FWCI
50.13
field-weighted impact
References
41
Percentile
100%
vs. same field & year
Citations per year
References
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*
Clinical Pharmacology & Therapeutics · 1997 · 683 citations
Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)*1
Clinical Pharmacology & Therapeutics · 1999 · 588 citations
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
British Journal of Clinical Pharmacology · 1998 · 844 citations
Trends in Alternative Medicine Use in the United States, 1990-1997
JAMA · 1998 · 6,690 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
